Phototransduction: Phototransduction in cones

V. J. Kefalov

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

6 Scopus citations


Cones use a phototransduction cascade similar to the one found in rods to convert light into an electric signal. Yet, cones have unique physiological properties, which make them better suited than rods for function under daylight conditions. Cones are significantly less sensitive than rods and their photoresponses are several times faster than those of rods. In addition, cones recover their sensitivity significantly faster following exposure to bright light and are able to adapt to an enormous range of background lights. These important functional differences between rods and cones are achieved by fine modulation of the reactions in their respective phototransduction cascades.

Original languageEnglish
Title of host publicationEncyclopedia of the Eye, Four-Volume Set
Number of pages8
ISBN (Electronic)9780123742032
ISBN (Print)9780123741981
StatePublished - Jan 1 2010


  • Arrestin
  • Chromophore
  • Dark adaptation
  • G-protein receptor kinase (GRK)
  • Guanylyl cyclase (GC)
  • Guanylyl cyclase activating protein (GCAP)
  • Light adaptation
  • Opsin
  • Phosphodiesterase (PDE)
  • Phototransduction
  • Pigment regeneration
  • Recoverin
  • Transducin
  • Visual cycle
  • cGMP-gated channel


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