Phototransduction in Rods and Cones

D. G. Luo; V. Kefalov; K. W. Yau

doi:10.1016/B978-012370880-9.00258-9

Phototransduction in Rods and Cones

D. G. Luo, V. Kefalov, K. W. Yau

Department of Ophthalmology and Visual Sciences

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

14 Scopus citations

Abstract

Phototransduction is the first step in seeing, whereby photons absorbed by the retinal rods and cones trigger an electrical signal, which is then transmitted synaptically to higher-order retinal neurons for processing. The mechanism of phototransduction is now extremely well understood, especially that of rods, and is in fact the exemplary G-protein-mediated signaling pathway understood down to quantitative details. The molecular identifications of the various proteins involved in phototransduction and their mutations have also helped understand many hereditary diseases affecting vision.

Original language	English
Title of host publication	Vision I
Publisher	Elsevier Inc.
Pages	269-301
Number of pages	33
Volume	1
ISBN (Print)	9780123708809
DOIs	https://doi.org/10.1016/B978-012370880-9.00258-9
State	Published - 2008

Keywords

Bleaching adaptation
CGMP
Ciliary photoreceptor
Cone
Cone pigment
Dark adaptation
Evolution
Light adaptation
Light response
Parietal eye
Photoreceptor
Phototransduction
Retina
Rhodopsin
Rod
Visual pigment

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title = "Phototransduction in Rods and Cones",

abstract = "Phototransduction is the first step in seeing, whereby photons absorbed by the retinal rods and cones trigger an electrical signal, which is then transmitted synaptically to higher-order retinal neurons for processing. The mechanism of phototransduction is now extremely well understood, especially that of rods, and is in fact the exemplary G-protein-mediated signaling pathway understood down to quantitative details. The molecular identifications of the various proteins involved in phototransduction and their mutations have also helped understand many hereditary diseases affecting vision.",

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AU - Luo, D. G.

AU - Kefalov, V.

AU - Yau, K. W.

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AB - Phototransduction is the first step in seeing, whereby photons absorbed by the retinal rods and cones trigger an electrical signal, which is then transmitted synaptically to higher-order retinal neurons for processing. The mechanism of phototransduction is now extremely well understood, especially that of rods, and is in fact the exemplary G-protein-mediated signaling pathway understood down to quantitative details. The molecular identifications of the various proteins involved in phototransduction and their mutations have also helped understand many hereditary diseases affecting vision.

KW - Bleaching adaptation

KW - CGMP

KW - Ciliary photoreceptor

KW - Cone

KW - Cone pigment

KW - Dark adaptation

KW - Evolution

KW - Light adaptation

KW - Light response

KW - Parietal eye

KW - Photoreceptor

KW - Phototransduction

KW - Retina

KW - Rhodopsin

KW - Rod

KW - Visual pigment

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M3 - Chapter

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SN - 9780123708809

VL - 1

SP - 269

EP - 301

BT - Vision I

PB - Elsevier Inc.

ER -

Phototransduction in Rods and Cones

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Keywords

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