Photothermal optical coherence tomography in ex vivo human breast tissues using gold nanoshells

Chao Zhou; Tsung Han Tsai; Desmond C. Adler; Hsiang Chieh Lee; David W. Cohen; Amy Mondelblatt; Yihong Wang; James L. Connolly; James G. Fujimoto

doi:10.1364/OL.35.000700

Photothermal optical coherence tomography in ex vivo human breast tissues using gold nanoshells

Chao Zhou, Tsung Han Tsai, Desmond C. Adler, Hsiang Chieh Lee, David W. Cohen, Amy Mondelblatt, Yihong Wang, James L. Connolly, James G. Fujimoto

Research output: Contribution to journal › Article › peer-review

89 Scopus citations

Abstract

We demonstrate photothermal optical coherence tomography (OCT) imaging in highly scattering human breast tissue ex vivo. A 120 kHz axial scan rate, swept-source phase-sensitive OCT system at 1300 nm was used to detect phase changes induced by 830 nm photothermal excitation of gold nanoshells. Localized phase modulation was observed 300-600 μm deep in scattering tissue using an excitation power of only 22 mW at modulation frequencies up to 20 kHz. This technique enables integrated structural and molecular-targeted imaging for cancer markers using nanoshells.

Original language	English
Pages (from-to)	700-702
Number of pages	3
Journal	Optics Letters
Volume	35
Issue number	5
DOIs	https://doi.org/10.1364/OL.35.000700
State	Published - Mar 1 2010

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abstract = "We demonstrate photothermal optical coherence tomography (OCT) imaging in highly scattering human breast tissue ex vivo. A 120 kHz axial scan rate, swept-source phase-sensitive OCT system at 1300 nm was used to detect phase changes induced by 830 nm photothermal excitation of gold nanoshells. Localized phase modulation was observed 300-600 μm deep in scattering tissue using an excitation power of only 22 mW at modulation frequencies up to 20 kHz. This technique enables integrated structural and molecular-targeted imaging for cancer markers using nanoshells.",

author = "Chao Zhou and Tsai, {Tsung Han} and Adler, {Desmond C.} and Lee, {Hsiang Chieh} and Cohen, {David W.} and Amy Mondelblatt and Yihong Wang and Connolly, {James L.} and Fujimoto, {James G.}",

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AU - Zhou, Chao

AU - Tsai, Tsung Han

AU - Adler, Desmond C.

AU - Lee, Hsiang Chieh

AU - Cohen, David W.

AU - Mondelblatt, Amy

AU - Wang, Yihong

AU - Connolly, James L.

AU - Fujimoto, James G.

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N2 - We demonstrate photothermal optical coherence tomography (OCT) imaging in highly scattering human breast tissue ex vivo. A 120 kHz axial scan rate, swept-source phase-sensitive OCT system at 1300 nm was used to detect phase changes induced by 830 nm photothermal excitation of gold nanoshells. Localized phase modulation was observed 300-600 μm deep in scattering tissue using an excitation power of only 22 mW at modulation frequencies up to 20 kHz. This technique enables integrated structural and molecular-targeted imaging for cancer markers using nanoshells.

AB - We demonstrate photothermal optical coherence tomography (OCT) imaging in highly scattering human breast tissue ex vivo. A 120 kHz axial scan rate, swept-source phase-sensitive OCT system at 1300 nm was used to detect phase changes induced by 830 nm photothermal excitation of gold nanoshells. Localized phase modulation was observed 300-600 μm deep in scattering tissue using an excitation power of only 22 mW at modulation frequencies up to 20 kHz. This technique enables integrated structural and molecular-targeted imaging for cancer markers using nanoshells.

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JO - Optics Letters

JF - Optics Letters

IS - 5

ER -

Photothermal optical coherence tomography in ex vivo human breast tissues using gold nanoshells

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