Photoreceptor degeneration changes magnetic resonance imaging features in a mouse model of retinitis pigmentosa

Qing Wang, Sheng Kwei Song, Huiying Zhang, Bruce A. Berkowitz, Shiming Chen, Samuel A. Wickline, Junjie Chen

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Retinal degeneration-1 (rd1) mice are animal models of retinitis pigmentosa, a blinding disease caused by photoreceptor cell degeneration. This study aims to determine magnetic resonance imaging (MRI) changes in retinas of 1- and 3-month-old rd1 mice. Apparent diffusion coefficient in retina was measured using diffusion MRI. The blood-retinal barrier leakage was evaluated using gadolinium-diethylenetriaminepentaacetic acid-enhanced T 1-weighted MRI before and after systemic gadolinium- diethylenetriaminepentaacetic acid injection. Photoreceptor degeneration in rd1 retina was apparent by decreased retinal thickness and loss of water diffusion anisotropy in both 1- and 3-month-old rd1 mice. Furthermore, statistically significant increase of mean retinal apparent diffusion coefficient and gadolinium-diethylenetriaminepentaacetic acid-enhanced T1-weighted MRI signals were observed in 3-month-old rd1 mice comparing with age-matched wild-type mice. Together, these data suggest that MRI parameter changes can signature common pathological changes in photoreceptor-degenerated eyes, particularly blood-retinal barrier leakage-induced retinal edema.

Original languageEnglish
Pages (from-to)1793-1798
Number of pages6
JournalMagnetic resonance in medicine
Volume65
Issue number6
DOIs
StatePublished - Jun 2011

Keywords

  • MRI
  • apparent diffusion coefficient
  • blood-retinal barrier
  • photoreceptor degeneration
  • rd1

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