Abstract
Light switching of the activity of a coiledcoil protein, the AP-1 transcription factor, in living cells was made possible by the introduction of a designed azobenzenecross-linked dominant negative peptide, XAFosW (red and yellow in the picture). In the dark, XAFosW showed decreased helical content and decreased affinity for target Jun proteins (green); irradiation at 365 nm enhanced helicity and target affinity. Chemical Equation Presentation
| Original language | English |
|---|---|
| Pages (from-to) | 3943-3946 |
| Number of pages | 4 |
| Journal | Angewandte Chemie - International Edition |
| Volume | 49 |
| Issue number | 23 |
| DOIs | |
| State | Published - May 25 2010 |
Keywords
- Azobenzene
- Isomerization
- Leucine zipper
- Peptides
- Photoswitches