Photoacoustic sentinel lymph node imaging with self-assembled copper neodecanoate nanoparticles

Dipanjan Pan, Xin Cai, Ceren Yalaz, Angana Senpan, Karthik Omanakuttan, Samuel A. Wickline, Lihong V. Wang, Gregory M. Lanza

Research output: Contribution to journalArticlepeer-review

73 Scopus citations

Abstract

Photoacoustic tomography (PAT) is emerging as a novel, hybrid, and non-ionizing imaging modality because of its satisfactory spatial resolution and high soft tissue contrast. PAT combines the advantages of both optical and ultrasonic imaging methods. It opens up the possibilities for noninvasive staging of breast cancer and may replace sentinel lymph node (SLN) biopsy in clinic in the near future. In this work, we demonstrate for the first time that copper can be used as a contrast metal for near-infrared detection of SLN using PAT. A unique strategy is adopted to encapsulate multiple copies of Cu as organically soluble small molecule complexes within a phospholipid-entrapped nanoparticle. The nanoparticles assumed a size of 80-90 nm, which is the optimum hydrodynamic diameter for its distribution throughout the lymphatic systems. These particles provided at least 6-fold higher signal sensitivity in comparison to blood, which is a natural absorber of light. We also demonstrated that high SLN detection sensitivity with PAT can be achieved in a rodent model. This work clearly demonstrates for the first time the potential use of copper as an optical contrast agent.

Original languageEnglish
Pages (from-to)1260-1267
Number of pages8
JournalACS nano
Volume6
Issue number2
DOIs
StatePublished - Feb 28 2012

Keywords

  • breast cancer staging
  • contrast agent
  • copper
  • nanoparticle
  • optical imaging
  • photoacoustic imaging
  • sentinel lymph node

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