Photoacoustic molecular imaging of angiogenesis using theranostic ανβ3-targeted copper nanoparticles incorporating a sn-2 lipase-labile fumagillin prodrug

Ruiying Zhang; Xin Cai; Xiaoxia Yang; Angana Senpan; John S. Allen; Dipanjan Pan; Gregory M. Lanza; Lihong V. Wang

doi:10.1117/12.2041120

Photoacoustic molecular imaging of angiogenesis using theranostic α_νβ₃-targeted copper nanoparticles incorporating a sn-2 lipase-labile fumagillin prodrug

Ruiying Zhang, Xin Cai, Xiaoxia Yang, Angana Senpan, John S. Allen, Dipanjan Pan, Gregory M. Lanza, Lihong V. Wang

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

3 Scopus citations

Abstract

Photoacoustic (PA) tomography imaging is an emerging, versatile, and noninvasive imaging modality, which combines the advantages of both optical imaging and ultrasound imaging. It opens up opportunities for noninvasive imaging of angiogenesis, a feature of skin pathologies including cancers and psoriasis. In this study, high-density copper oleate encapsulated within a phospholipid surfactant (CuNPs) generated a soft nanoparticle with PA contrast comparable to gold. Within the near-infrared window, the copper nanoparticles can provide a signal more than 7 times higher that of blood. ανβ3-targeted of CuNPs in a Matrigel mouse model demonstrated prominent PA contrast enhancement of the neovasculature compared to mice given nontargeted or competitively inhibited CuNPs. Incorporation of a sn-2 lipase-labile fumagillin prodrug into the CuNPs produced marked antiangiogenesis in the same model, demonstrating the theranostic potential of a PA agent for the first time in vivo. With a PA signal comparable to gold-based nanoparticles yet a lower cost and demonstrated drug delivery potential, ανβ3- targeted CuNPs hold great promise for the management of skin pathologies with neovascular features.

Original language	English
Title of host publication	Photons Plus Ultrasound
Subtitle of host publication	Imaging and Sensing 2014
Publisher	SPIE
ISBN (Print)	9780819498564
DOIs	https://doi.org/10.1117/12.2041120
State	Published - 2014
Event	Photons Plus Ultrasound: Imaging and Sensing 2014 - San Francisco, CA, United States Duration: Feb 2 2014 → Feb 5 2014

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	8943
ISSN (Print)	1605-7422

Conference

Conference	Photons Plus Ultrasound: Imaging and Sensing 2014
Country/Territory	United States
City	San Francisco, CA
Period	02/2/14 → 02/5/14

Keywords

Angiogenesis
Antiangiogenic therapy
Copper nanoparticles
Fumagillin prodrug
Photoacoustic molecular imaging

Access to Document

10.1117/12.2041120

Cite this

Zhang, R., Cai, X., Yang, X., Senpan, A., Allen, J. S., Pan, D., Lanza, G. M., & Wang, L. V. (2014). Photoacoustic molecular imaging of angiogenesis using theranostic α_νβ₃-targeted copper nanoparticles incorporating a sn-2 lipase-labile fumagillin prodrug. In Photons Plus Ultrasound: Imaging and Sensing 2014 Article 89435I (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 8943). SPIE. https://doi.org/10.1117/12.2041120

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title = "Photoacoustic molecular imaging of angiogenesis using theranostic ανβ3-targeted copper nanoparticles incorporating a sn-2 lipase-labile fumagillin prodrug",

abstract = "Photoacoustic (PA) tomography imaging is an emerging, versatile, and noninvasive imaging modality, which combines the advantages of both optical imaging and ultrasound imaging. It opens up opportunities for noninvasive imaging of angiogenesis, a feature of skin pathologies including cancers and psoriasis. In this study, high-density copper oleate encapsulated within a phospholipid surfactant (CuNPs) generated a soft nanoparticle with PA contrast comparable to gold. Within the near-infrared window, the copper nanoparticles can provide a signal more than 7 times higher that of blood. ανβ3-targeted of CuNPs in a Matrigel mouse model demonstrated prominent PA contrast enhancement of the neovasculature compared to mice given nontargeted or competitively inhibited CuNPs. Incorporation of a sn-2 lipase-labile fumagillin prodrug into the CuNPs produced marked antiangiogenesis in the same model, demonstrating the theranostic potential of a PA agent for the first time in vivo. With a PA signal comparable to gold-based nanoparticles yet a lower cost and demonstrated drug delivery potential, ανβ3- targeted CuNPs hold great promise for the management of skin pathologies with neovascular features.",

keywords = "Angiogenesis, Antiangiogenic therapy, Copper nanoparticles, Fumagillin prodrug, Photoacoustic molecular imaging",

author = "Ruiying Zhang and Xin Cai and Xiaoxia Yang and Angana Senpan and Allen, {John S.} and Dipanjan Pan and Lanza, {Gregory M.} and Wang, {Lihong V.}",

year = "2014",

doi = "10.1117/12.2041120",

language = "English",

isbn = "9780819498564",

series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",

publisher = "SPIE",

booktitle = "Photons Plus Ultrasound",

note = "Photons Plus Ultrasound: Imaging and Sensing 2014 ; Conference date: 02-02-2014 Through 05-02-2014",

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Zhang, R, Cai, X, Yang, X, Senpan, A, Allen, JS, Pan, D, Lanza, GM & Wang, LV 2014, Photoacoustic molecular imaging of angiogenesis using theranostic α_νβ₃-targeted copper nanoparticles incorporating a sn-2 lipase-labile fumagillin prodrug. in Photons Plus Ultrasound: Imaging and Sensing 2014., 89435I, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 8943, SPIE, Photons Plus Ultrasound: Imaging and Sensing 2014, San Francisco, CA, United States, 02/2/14. https://doi.org/10.1117/12.2041120

Photoacoustic molecular imaging of angiogenesis using theranostic α_νβ₃-targeted copper nanoparticles incorporating a sn-2 lipase-labile fumagillin prodrug. / Zhang, Ruiying; Cai, Xin; Yang, Xiaoxia et al.
Photons Plus Ultrasound: Imaging and Sensing 2014. SPIE, 2014. 89435I (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 8943).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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AU - Cai, Xin

AU - Yang, Xiaoxia

AU - Senpan, Angana

AU - Allen, John S.

AU - Pan, Dipanjan

AU - Lanza, Gregory M.

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N2 - Photoacoustic (PA) tomography imaging is an emerging, versatile, and noninvasive imaging modality, which combines the advantages of both optical imaging and ultrasound imaging. It opens up opportunities for noninvasive imaging of angiogenesis, a feature of skin pathologies including cancers and psoriasis. In this study, high-density copper oleate encapsulated within a phospholipid surfactant (CuNPs) generated a soft nanoparticle with PA contrast comparable to gold. Within the near-infrared window, the copper nanoparticles can provide a signal more than 7 times higher that of blood. ανβ3-targeted of CuNPs in a Matrigel mouse model demonstrated prominent PA contrast enhancement of the neovasculature compared to mice given nontargeted or competitively inhibited CuNPs. Incorporation of a sn-2 lipase-labile fumagillin prodrug into the CuNPs produced marked antiangiogenesis in the same model, demonstrating the theranostic potential of a PA agent for the first time in vivo. With a PA signal comparable to gold-based nanoparticles yet a lower cost and demonstrated drug delivery potential, ανβ3- targeted CuNPs hold great promise for the management of skin pathologies with neovascular features.

AB - Photoacoustic (PA) tomography imaging is an emerging, versatile, and noninvasive imaging modality, which combines the advantages of both optical imaging and ultrasound imaging. It opens up opportunities for noninvasive imaging of angiogenesis, a feature of skin pathologies including cancers and psoriasis. In this study, high-density copper oleate encapsulated within a phospholipid surfactant (CuNPs) generated a soft nanoparticle with PA contrast comparable to gold. Within the near-infrared window, the copper nanoparticles can provide a signal more than 7 times higher that of blood. ανβ3-targeted of CuNPs in a Matrigel mouse model demonstrated prominent PA contrast enhancement of the neovasculature compared to mice given nontargeted or competitively inhibited CuNPs. Incorporation of a sn-2 lipase-labile fumagillin prodrug into the CuNPs produced marked antiangiogenesis in the same model, demonstrating the theranostic potential of a PA agent for the first time in vivo. With a PA signal comparable to gold-based nanoparticles yet a lower cost and demonstrated drug delivery potential, ανβ3- targeted CuNPs hold great promise for the management of skin pathologies with neovascular features.

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KW - Antiangiogenic therapy

KW - Copper nanoparticles

KW - Fumagillin prodrug

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M3 - Conference contribution

AN - SCOPUS:84902105232

SN - 9780819498564

T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

BT - Photons Plus Ultrasound

PB - SPIE

T2 - Photons Plus Ultrasound: Imaging and Sensing 2014

Y2 - 2 February 2014 through 5 February 2014

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Zhang R, Cai X, Yang X, Senpan A, Allen JS, Pan D et al. Photoacoustic molecular imaging of angiogenesis using theranostic α_νβ₃-targeted copper nanoparticles incorporating a sn-2 lipase-labile fumagillin prodrug. In Photons Plus Ultrasound: Imaging and Sensing 2014. SPIE. 2014. 89435I. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE). doi: 10.1117/12.2041120