@inproceedings{f4d7444a15bb4a37aaf8cff8c79a65a4,
title = "Photoacoustic microscopy of neovascularization in three-dimensional porous scaffolds",
abstract = "It is a challenge to non-invasively visualize in vivo the neovascularization in a three-dimensional (3D) scaffold with high spatial resolution and deep penetration depth. Here we used photoacoustic microscopy (PAM) to chronically monitor neovascularization in an inverse opal scaffold implanted in a mouse model for up to six weeks. The neovasculature was observed to develop gradually in the same mouse. These blood vessels not only grew on top of the implanted scaffold but also penetrated into the scaffold. The PAM system offered a lateral resolution of ∼45 μm and a penetration depth of ∼3 mm into the scaffold/tissue construct. By using the 3D PAM data, we further quantified the vessel area as a function of time.",
keywords = "Three-dimensional scaffold, biomedical imaging, neovascularization, photoacoustic microscopy, tissue engineering",
author = "Xin Cai and Yu Zhang and Li Li and Choi, {Sung Wook} and MacEwan, {Matthew R.} and Junjie Yao and Chulhong Kim and Younan Xia and Wang, {Lihong V.}",
year = "2013",
doi = "10.1117/12.2005236",
language = "English",
isbn = "9780819493507",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
booktitle = "Photons Plus Ultrasound",
note = "Photons Plus Ultrasound: Imaging and Sensing 2013 ; Conference date: 03-02-2013 Through 05-02-2013",
}