Phosphorylation of krüppel-like factor 3 (KLF3/BKLF) and C-terminal binding protein 2 (CtBP2) by homeodomaininteracting protein kinase 2 (HIPK2) modulates KLF3 DNA binding and activity

Vitri Dewi; Alister Kwok; Stella Lee; Ming Min Lee; Yee Mun Tan; Hannah R. Nicholas; Kyo Ichi Isono; Beeke Wienert; Ka Sin Mak; Alexander J. Knights; Kate G.R. Quinlan; Stuart J. Cordwell; Alister P.W. Funnell; Richard C.M. Pearson; Merlin Crossley

doi:10.1074/jbc.M115.638338

Phosphorylation of krüppel-like factor 3 (KLF3/BKLF) and C-terminal binding protein 2 (CtBP2) by homeodomaininteracting protein kinase 2 (HIPK2) modulates KLF3 DNA binding and activity

Vitri Dewi
, Alister Kwok
, Stella Lee
, Ming Min Lee
, Yee Mun Tan
, Hannah R. Nicholas
, Kyo Ichi Isono
, Beeke Wienert
, Ka Sin Mak
, Alexander J. Knights
, Kate G.R. Quinlan
, Stuart J. Cordwell
, Alister P.W. Funnell
, Richard C.M. Pearson
, Merlin Crossley

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Background: Krüppel-like factor 3 (KLF3) is a transcriptional repressor with multiple biological roles. Results: Phosphorylation of KLF3 by homeodomain-interacting protein kinase 2 (HIPK2) promotes DNA binding and transcriptional repression. Conclusion: Signal transduction pathways mediated by HIPK2 control and direct KLF3 activity. Significance: Determining the pathways that control KLF3 function offers potential for regulating its activity for therapeutic benefit.

Original language	English
Pages (from-to)	8591-8605
Number of pages	15
Journal	Journal of Biological Chemistry
Volume	290
Issue number	13
DOIs	https://doi.org/10.1074/jbc.M115.638338
State	Published - Mar 27 2015

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10.1074/jbc.M115.638338

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Dewi, V., Kwok, A., Lee, S., Lee, M. M., Tan, Y. M., Nicholas, H. R., Isono, K. I., Wienert, B., Mak, K. S., Knights, A. J., Quinlan, K. G. R., Cordwell, S. J., Funnell, A. P. W., Pearson, R. C. M., & Crossley, M. (2015). Phosphorylation of krüppel-like factor 3 (KLF3/BKLF) and C-terminal binding protein 2 (CtBP2) by homeodomaininteracting protein kinase 2 (HIPK2) modulates KLF3 DNA binding and activity. Journal of Biological Chemistry, 290(13), 8591-8605. https://doi.org/10.1074/jbc.M115.638338

@article{9c3b27493aef4a0bab2e95c9c21a8f14,

title = "Phosphorylation of kr{\"u}ppel-like factor 3 (KLF3/BKLF) and C-terminal binding protein 2 (CtBP2) by homeodomaininteracting protein kinase 2 (HIPK2) modulates KLF3 DNA binding and activity",

abstract = "Background: Kr{\"u}ppel-like factor 3 (KLF3) is a transcriptional repressor with multiple biological roles. Results: Phosphorylation of KLF3 by homeodomain-interacting protein kinase 2 (HIPK2) promotes DNA binding and transcriptional repression. Conclusion: Signal transduction pathways mediated by HIPK2 control and direct KLF3 activity. Significance: Determining the pathways that control KLF3 function offers potential for regulating its activity for therapeutic benefit.",

author = "Vitri Dewi and Alister Kwok and Stella Lee and Lee, \{Ming Min\} and Tan, \{Yee Mun\} and Nicholas, \{Hannah R.\} and Isono, \{Kyo Ichi\} and Beeke Wienert and Mak, \{Ka Sin\} and Knights, \{Alexander J.\} and Quinlan, \{Kate G.R.\} and Cordwell, \{Stuart J.\} and Funnell, \{Alister P.W.\} and Pearson, \{Richard C.M.\} and Merlin Crossley",

note = "Publisher Copyright: {\textcopyright} 2015 by The American Society for Biochemistry and Molecular Biology, Inc.",

year = "2015",

month = mar,

day = "27",

doi = "10.1074/jbc.M115.638338",

language = "English",

volume = "290",

pages = "8591--8605",

journal = "Journal of Biological Chemistry",

issn = "0021-9258",

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Dewi, V, Kwok, A, Lee, S, Lee, MM, Tan, YM, Nicholas, HR, Isono, KI, Wienert, B, Mak, KS, Knights, AJ, Quinlan, KGR, Cordwell, SJ, Funnell, APW, Pearson, RCM & Crossley, M 2015, 'Phosphorylation of krüppel-like factor 3 (KLF3/BKLF) and C-terminal binding protein 2 (CtBP2) by homeodomaininteracting protein kinase 2 (HIPK2) modulates KLF3 DNA binding and activity', Journal of Biological Chemistry, vol. 290, no. 13, pp. 8591-8605. https://doi.org/10.1074/jbc.M115.638338

Phosphorylation of krüppel-like factor 3 (KLF3/BKLF) and C-terminal binding protein 2 (CtBP2) by homeodomaininteracting protein kinase 2 (HIPK2) modulates KLF3 DNA binding and activity. / Dewi, Vitri; Kwok, Alister; Lee, Stella et al.
In: Journal of Biological Chemistry, Vol. 290, No. 13, 27.03.2015, p. 8591-8605.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Phosphorylation of krüppel-like factor 3 (KLF3/BKLF) and C-terminal binding protein 2 (CtBP2) by homeodomaininteracting protein kinase 2 (HIPK2) modulates KLF3 DNA binding and activity

AU - Dewi, Vitri

AU - Kwok, Alister

AU - Lee, Stella

AU - Lee, Ming Min

AU - Tan, Yee Mun

AU - Nicholas, Hannah R.

AU - Isono, Kyo Ichi

AU - Wienert, Beeke

AU - Mak, Ka Sin

AU - Knights, Alexander J.

AU - Quinlan, Kate G.R.

AU - Cordwell, Stuart J.

AU - Funnell, Alister P.W.

AU - Pearson, Richard C.M.

AU - Crossley, Merlin

PY - 2015/3/27

Y1 - 2015/3/27

N2 - Background: Krüppel-like factor 3 (KLF3) is a transcriptional repressor with multiple biological roles. Results: Phosphorylation of KLF3 by homeodomain-interacting protein kinase 2 (HIPK2) promotes DNA binding and transcriptional repression. Conclusion: Signal transduction pathways mediated by HIPK2 control and direct KLF3 activity. Significance: Determining the pathways that control KLF3 function offers potential for regulating its activity for therapeutic benefit.

AB - Background: Krüppel-like factor 3 (KLF3) is a transcriptional repressor with multiple biological roles. Results: Phosphorylation of KLF3 by homeodomain-interacting protein kinase 2 (HIPK2) promotes DNA binding and transcriptional repression. Conclusion: Signal transduction pathways mediated by HIPK2 control and direct KLF3 activity. Significance: Determining the pathways that control KLF3 function offers potential for regulating its activity for therapeutic benefit.

UR - https://www.scopus.com/pages/publications/84925831813

U2 - 10.1074/jbc.M115.638338

DO - 10.1074/jbc.M115.638338

M3 - Article

C2 - 25659434

AN - SCOPUS:84925831813

SN - 0021-9258

VL - 290

SP - 8591

EP - 8605

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 13

ER -

Phosphorylation of krüppel-like factor 3 (KLF3/BKLF) and C-terminal binding protein 2 (CtBP2) by homeodomaininteracting protein kinase 2 (HIPK2) modulates KLF3 DNA binding and activity

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