Phosphoproteomics Illuminates Opioid Actions

Tao Che, Bryan L. Roth

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations


Opioids are widely used analgesic medications with a high potential for tolerance and dependence and represent a frequent cause of death due to overdose. Opioids mediate their actions via a family of opioid G protein coupled receptors. Elucidating the biochemical mechanism(s) responsible for both the therapeutic and deleterious side effects of opioids could provide a biochemical roadmap for selectively targeting therapeutic signaling pathways. Here we provide a perspective on emerging findings, which illuminate these signaling pathways via unbiased and quantitative phosphoproteomic analysis. What emerged from these studies is the discovery that certain deleterious actions mediated by the κ opioid receptors appear due to specific activation of mTOR pathways. The findings imply that designing drugs, which bypass mTOR signaling, could yield safer and more effective analgesics.

Original languageEnglish
Pages (from-to)5505-5506
Number of pages2
Issue number38
StatePublished - Sep 25 2018


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