@article{9b6fc38eb4504cabb6ebd2c89e3b49a2,
title = "Phospho-Ser784-VCP Is Required for DNA Damage Response and Is Associated with Poor Prognosis of Chemotherapy-Treated Breast Cancer",
abstract = "Zhu et al. show that DNA-damage-induced, PIKK-mediated Ser784 phosphorylation is a specific enhancer of VCP function in chromatin-associated protein degradation. Phospho-Ser784-VCP is required for DNA repair, checkpoint signaling, and cell survival in response to a broad range of genotoxins and correlates with poor outcome among chemotherapy-treated breast cancer patients.",
keywords = "DNA damage response, K48-linked polyubiquitin, VCP, biomarker, cancer, chemotherapy, chromatin-associated degradation, nucleus, phosphorylation, proteostasis",
author = "Cuige Zhu and Anna Rogers and Karama Asleh and Jennifer Won and Dongxia Gao and Samuel Leung and Shan Li and Vij, {Kiran R.} and Jian Zhu and Held, {Jason M.} and Zhongsheng You and Nielsen, {Torsten O.} and Jieya Shao",
note = "Funding Information: We thank Dr. Matthew Ellis, Dr. Sherri Davies, and Jacqueline Snider for providing the SPECS TMA. We thank Dr. Craig Allred and Lin Li for help with the IHC. We thank Dr. Nima Mosammaparast and Andrea Byrum for help with DNA-damage foci analysis. J.S. was supported by the Longer Life Foundation Research Development Award ( 2014-006 ), Susan G. Komen Foundation Career Catalyst Research Grant ( CCR14300139 ), Siteman Investment Program Pre-R01 Award ( 3948 ), and a National Cancer Institute R01 grant ( 5R01CA181671 ). Publisher Copyright: {\textcopyright} 2020 The Author(s)",
year = "2020",
month = jun,
day = "9",
doi = "10.1016/j.celrep.2020.107745",
language = "English",
volume = "31",
journal = "Cell Reports",
issn = "2211-1247",
number = "10",
}