Zhu et al. show that DNA-damage-induced, PIKK-mediated Ser784 phosphorylation is a specific enhancer of VCP function in chromatin-associated protein degradation. Phospho-Ser784-VCP is required for DNA repair, checkpoint signaling, and cell survival in response to a broad range of genotoxins and correlates with poor outcome among chemotherapy-treated breast cancer patients.

Original languageEnglish
Article number107745
JournalCell Reports
Issue number10
StatePublished - Jun 9 2020


  • DNA damage response
  • K48-linked polyubiquitin
  • VCP
  • biomarker
  • cancer
  • chemotherapy
  • chromatin-associated degradation
  • nucleus
  • phosphorylation
  • proteostasis


Dive into the research topics of 'Phospho-Ser784-VCP Is Required for DNA Damage Response and Is Associated with Poor Prognosis of Chemotherapy-Treated Breast Cancer'. Together they form a unique fingerprint.

Cite this