Phospho-Ser784-VCP Is Required for DNA Damage Response and Is Associated with Poor Prognosis of Chemotherapy-Treated Breast Cancer

Cuige Zhu; Anna Rogers; Karama Asleh; Jennifer Won; Dongxia Gao; Samuel Leung; Shan Li; Kiran R. Vij; Jian Zhu; Jason M. Held; Zhongsheng You; Torsten O. Nielsen; Jieya Shao

doi:10.1016/j.celrep.2020.107745

Phospho-Ser⁷⁸⁴-VCP Is Required for DNA Damage Response and Is Associated with Poor Prognosis of Chemotherapy-Treated Breast Cancer

Cuige Zhu, Anna Rogers, Karama Asleh, Jennifer Won, Dongxia Gao, Samuel Leung, Shan Li, Kiran R. Vij, Jian Zhu, Jason M. Held, Zhongsheng You, Torsten O. Nielsen, Jieya Shao

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Zhu et al. show that DNA-damage-induced, PIKK-mediated Ser⁷⁸⁴ phosphorylation is a specific enhancer of VCP function in chromatin-associated protein degradation. Phospho-Ser⁷⁸⁴-VCP is required for DNA repair, checkpoint signaling, and cell survival in response to a broad range of genotoxins and correlates with poor outcome among chemotherapy-treated breast cancer patients.

Original language	English
Article number	107745
Journal	Cell Reports
Volume	31
Issue number	10
DOIs	https://doi.org/10.1016/j.celrep.2020.107745
State	Published - Jun 9 2020

Keywords

DNA damage response
K48-linked polyubiquitin
VCP
biomarker
cancer
chemotherapy
chromatin-associated degradation
nucleus
phosphorylation
proteostasis

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10.1016/j.celrep.2020.107745

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title = "Phospho-Ser784-VCP Is Required for DNA Damage Response and Is Associated with Poor Prognosis of Chemotherapy-Treated Breast Cancer",

abstract = "Zhu et al. show that DNA-damage-induced, PIKK-mediated Ser784 phosphorylation is a specific enhancer of VCP function in chromatin-associated protein degradation. Phospho-Ser784-VCP is required for DNA repair, checkpoint signaling, and cell survival in response to a broad range of genotoxins and correlates with poor outcome among chemotherapy-treated breast cancer patients.",

keywords = "DNA damage response, K48-linked polyubiquitin, VCP, biomarker, cancer, chemotherapy, chromatin-associated degradation, nucleus, phosphorylation, proteostasis",

author = "Cuige Zhu and Anna Rogers and Karama Asleh and Jennifer Won and Dongxia Gao and Samuel Leung and Shan Li and Vij, {Kiran R.} and Jian Zhu and Held, {Jason M.} and Zhongsheng You and Nielsen, {Torsten O.} and Jieya Shao",

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year = "2020",

month = jun,

day = "9",

doi = "10.1016/j.celrep.2020.107745",

language = "English",

volume = "31",

journal = "Cell Reports",

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T1 - Phospho-Ser784-VCP Is Required for DNA Damage Response and Is Associated with Poor Prognosis of Chemotherapy-Treated Breast Cancer

AU - Zhu, Cuige

AU - Rogers, Anna

AU - Asleh, Karama

AU - Won, Jennifer

AU - Gao, Dongxia

AU - Leung, Samuel

AU - Li, Shan

AU - Vij, Kiran R.

AU - Zhu, Jian

AU - Held, Jason M.

AU - You, Zhongsheng

AU - Nielsen, Torsten O.

AU - Shao, Jieya

PY - 2020/6/9

Y1 - 2020/6/9

N2 - Zhu et al. show that DNA-damage-induced, PIKK-mediated Ser784 phosphorylation is a specific enhancer of VCP function in chromatin-associated protein degradation. Phospho-Ser784-VCP is required for DNA repair, checkpoint signaling, and cell survival in response to a broad range of genotoxins and correlates with poor outcome among chemotherapy-treated breast cancer patients.

AB - Zhu et al. show that DNA-damage-induced, PIKK-mediated Ser784 phosphorylation is a specific enhancer of VCP function in chromatin-associated protein degradation. Phospho-Ser784-VCP is required for DNA repair, checkpoint signaling, and cell survival in response to a broad range of genotoxins and correlates with poor outcome among chemotherapy-treated breast cancer patients.

KW - DNA damage response

KW - K48-linked polyubiquitin

KW - VCP

KW - biomarker

KW - cancer

KW - chemotherapy

KW - chromatin-associated degradation

KW - nucleus

KW - phosphorylation

KW - proteostasis

UR - http://www.scopus.com/inward/record.url?scp=85085944077&partnerID=8YFLogxK

U2 - 10.1016/j.celrep.2020.107745

DO - 10.1016/j.celrep.2020.107745

M3 - Article

C2 - 32521270

AN - SCOPUS:85085944077

SN - 2639-1856

VL - 31

JO - Cell Reports

JF - Cell Reports

IS - 10

M1 - 107745

ER -

Phospho-Ser⁷⁸⁴-VCP Is Required for DNA Damage Response and Is Associated with Poor Prognosis of Chemotherapy-Treated Breast Cancer

Abstract

Keywords

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