Phospho-Ser784-VCP Is Required for DNA Damage Response and Is Associated with Poor Prognosis of Chemotherapy-Treated Breast Cancer

Cuige Zhu, Anna Rogers, Karama Asleh, Jennifer Won, Dongxia Gao, Samuel Leung, Shan Li, Kiran R. Vij, Jian Zhu, Jason M. Held, Zhongsheng You, Torsten O. Nielsen, Jieya Shao

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Zhu et al. show that DNA-damage-induced, PIKK-mediated Ser784 phosphorylation is a specific enhancer of VCP function in chromatin-associated protein degradation. Phospho-Ser784-VCP is required for DNA repair, checkpoint signaling, and cell survival in response to a broad range of genotoxins and correlates with poor outcome among chemotherapy-treated breast cancer patients.

Original languageEnglish
Article number107745
JournalCell Reports
Volume31
Issue number10
DOIs
StatePublished - Jun 9 2020

Keywords

  • biomarker
  • cancer
  • chemotherapy
  • chromatin-associated degradation
  • DNA damage response
  • K48-linked polyubiquitin
  • nucleus
  • phosphorylation
  • proteostasis
  • VCP

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