Phosphate, oxidative stress, and nuclear factor-B activation in vascular calcification

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Phosphate-induced vascular calcification, characterized by induction of osteogenic programs, mineral vesicle release, and apoptosis, is prevalent in patients with kidney disease. Zhao et al. provide a mechanistic link between phosphate-induced calcification and increased mitochondrial membrane potential, increased mitochondrial reactive oxygen species, activation of the nuclear factor-B pathway, and subsequent expression of osteogenic genes and vascular mineralization. This link clarifies the intracellular mechanism of vascular calcification and may allow exploration of antioxidants as therapeutic agents for vascular calcification.

Original languageEnglish
Pages (from-to)1044-1047
Number of pages4
JournalKidney International
Issue number10
StatePublished - May 2011


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