Phosphate homeostasis in CKD: Report of a scientific symposium sponsored by the national kidney foundation

Geoffrey A. Block, Joachim H. Ix, Markus Ketteler, Kevin J. Martin, Ravi I. Thadhani, Marcello Tonelli, Myles Wolf, Harald Jüppner, Keith Hruska, David C. Wheeler

Research output: Contribution to journalArticlepeer-review

60 Scopus citations

Abstract

Chronic kidney disease (CKD)-mineral and bone disorder is associated with diverse metabolic and endocrine disturbances that ultimately may contribute to further loss of kidney function, bone demineralization, and fatal or nonfatal cardiovascular events. Recent insights into the pathophysiology of the events that unfold during the development of this disorder suggest that disturbances in phosphate metabolism are pivotal. The consequences of abnormal phosphate homeostasis are evident at estimated glomerular filtration rates <70 mL/min/1.73 m2, long before serum phosphate levels increase. Healthy individuals with blood phosphate levels in the top quartile of the normal range have an increased risk of developing CKD, reaching end-stage renal disease, and experiencing cardiovascular events. Substantial public health consequences may be related to increased dietary phosphorus exposure from additives that contain phosphate in the food supply and from modest increases in serum phosphate levels; however, it remains to be established whether interventions aimed at these targets can impact on the development of adverse clinical outcomes. Current approaches involving dietary intervention and intestinal phosphate binders are based on principles and assumptions that need to be examined more rigorously. Compelling animal, observational, and clinical data indicate that interventions directed at lowering phosphate exposure and serum phosphate levels should be subject to rigorous clinical trials that use appropriate placebo comparators and focus on key clinical outcomes, such as cardiovascular events, progression of CKD, fractures, quality of life, and mortality.

Original languageEnglish
Pages (from-to)457-473
Number of pages17
JournalAmerican Journal of Kidney Diseases
Volume62
Issue number3
DOIs
StatePublished - Sep 2013

Keywords

  • Phosphate
  • chronic kidney disease
  • chronic kidney disease-mineral and bone disorder (CKD-MBD)
  • diet
  • food labeling

Fingerprint

Dive into the research topics of 'Phosphate homeostasis in CKD: Report of a scientific symposium sponsored by the national kidney foundation'. Together they form a unique fingerprint.

Cite this