Phosphate accumulation by the isolated renal tubule and the effects of parathyroid hormone and cyclic adenosine monophosphate

Edward M. Rosenberg, Sook Won Lee, Lewis R. Chase, Louis V. Avioli

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

The effects of metabolic and transport inhibitors and PTH, cAMP, db-cAMP, and theophylline on Pi uptake by an isolated rat renal tubular preparation has been investigated. Pi uptake by this preparation was a saturable process, was O2 and sodium-dependent, was inactivated by heat-treatment, and was inhibited by dinitrophenol, iodacetate, ouabain, and a decrease in temperature from 37 ° to 4 °C. PTH and cAMP stimulated Pi uptake by energy-dependent and ouabain-inhibitable mechanisms.

Original languageEnglish
Pages (from-to)24-35
Number of pages12
JournalJournal of Laboratory and Clinical Medicine
Volume96
Issue number1
StatePublished - Jan 1 1980

Keywords

  • 2
  • 4-dinitrophenyl
  • 5 diphenyloxazole
  • 5′-cyclic monophosphate
  • BSA
  • DNP
  • EGTA
  • KRB
  • Krebs-Ringer bicarbonate
  • PAH
  • PTH
  • Pi
  • TCA
  • TLC
  • adenosine 3′
  • bovine serum albumin
  • cAMP
  • cGMP
  • cyclic guanosine monophosphate
  • db-cAMP
  • dibutyryl cAMP
  • ethyleneglycol tetraacetic acid
  • p-bis-2(5-phenyloxazolyl) and 2
  • para-aminohippuric acid
  • parathyroid hormone
  • phosphate
  • trichloroacetic acid

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