Phorbol-ester stimulated lysis of weak and nonspecific target cells by cytotoxic T lymphocytes

J. H. Russell

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20 Scopus citations

Abstract

We have investigated the effects of short-term incubation of cloned and in vivo-produced cytotoxic T lymphocytes (CTL) with phorbol esters on their lytic activity against weak and nonspecific targets. These experiments demonstrate that 4β-phorbol-12-myristate, 13-acetate (PMA), 4β-phorbol-12,13-dibutyrate, and 4β-phorbol-12,13-didecanoate, but not the 4α-phorbol-12,13 didecanoate esters stimulate the lytic apparatus. The stimulation is specific for the CTL rather than the target and appears to be nearly instantaneous in action. This rapid stimulation of the CTL lytic process is consistent with previously reported effects of phorbol esters associated with T cell activation in other functional assays.

Original languageEnglish
Pages (from-to)23-27
Number of pages5
JournalJournal of Immunology
Volume136
Issue number1
StatePublished - 1986

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