TY - JOUR
T1 - Phenotypic variation and intracellular parasitism by Histoplasma capsulatum
AU - Kügler, Silke
AU - Sebghati, Tricia Schurtz
AU - Eissenberg, Linda Groppe
AU - Goldman, William E.
PY - 2000/8/1
Y1 - 2000/8/1
N2 - The success of Histoplasma capsulatum as an intracellular pathogen depends completely on successful conversion of the saprophytic mycelial (mold) form of this fungus to a parasitic yeast form. it is therefore not surprising that yeast phase-specific genes and gene products are proving to be important for survival and proliferation of H. capsulatum within macrophages. In this study, we have focused on the role and regulation of two yeast-specific characteristics: α-(1,3)-glucan, a cell wall polysaccharide modulated by cell-density (quorum) sensing, and a secreted calcium-binding protein (CBP) that is essential for pathogenicity.
AB - The success of Histoplasma capsulatum as an intracellular pathogen depends completely on successful conversion of the saprophytic mycelial (mold) form of this fungus to a parasitic yeast form. it is therefore not surprising that yeast phase-specific genes and gene products are proving to be important for survival and proliferation of H. capsulatum within macrophages. In this study, we have focused on the role and regulation of two yeast-specific characteristics: α-(1,3)-glucan, a cell wall polysaccharide modulated by cell-density (quorum) sensing, and a secreted calcium-binding protein (CBP) that is essential for pathogenicity.
UR - http://www.scopus.com/inward/record.url?scp=0034255498&partnerID=8YFLogxK
U2 - 10.1073/pnas.97.16.8794
DO - 10.1073/pnas.97.16.8794
M3 - Article
C2 - 10922037
AN - SCOPUS:0034255498
SN - 0027-8424
VL - 97
SP - 8794
EP - 8798
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 16
ER -