Phenotypic variation and intracellular parasitism by Histoplasma capsulatum

Silke Kügler, Tricia Schurtz Sebghati, Linda Groppe Eissenberg, William E. Goldman

Research output: Contribution to journalArticlepeer-review

69 Scopus citations

Abstract

The success of Histoplasma capsulatum as an intracellular pathogen depends completely on successful conversion of the saprophytic mycelial (mold) form of this fungus to a parasitic yeast form. it is therefore not surprising that yeast phase-specific genes and gene products are proving to be important for survival and proliferation of H. capsulatum within macrophages. In this study, we have focused on the role and regulation of two yeast-specific characteristics: α-(1,3)-glucan, a cell wall polysaccharide modulated by cell-density (quorum) sensing, and a secreted calcium-binding protein (CBP) that is essential for pathogenicity.

Original languageEnglish
Pages (from-to)8794-8798
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume97
Issue number16
DOIs
StatePublished - Aug 1 2000

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