Phenotype of mice lacking functional Deleted in colorectal cancer (Dcc) gene

Amin Fazeli; Stephanie L. Dickinson; Michelle L. Hermiston; Robert V. Tighe; Robert G. Steen; Clayton G. Small; Esther T. Stoeckli; Kazuko Keino-Masu; Masayuki Masu; Helen Rayburn; Jonathan Simons; Roderick T. Bronson; Jeffrey I. Gordon; Marc Tessier-Lavigne; Robert A. Weinberg

doi:10.1038/386796a0

Phenotype of mice lacking functional Deleted in colorectal cancer (Dcc) gene

Amin Fazeli
, Stephanie L. Dickinson
, Michelle L. Hermiston
, Robert V. Tighe
, Robert G. Steen
, Clayton G. Small
, Esther T. Stoeckli
, Kazuko Keino-Masu
, Masayuki Masu
, Helen Rayburn
, Jonathan Simons
, Roderick T. Bronson
, Jeffrey I. Gordon
, Marc Tessier-Lavigne
, Robert A. Weinberg

Research output: Contribution to journal › Article › peer-review

701 Scopus citations

Abstract

The DCC (Deleted in colorectal cancer) gene was first identified us u candidate for a tumour-suppressor gene on human chromosome 18q. Moro recently, in vitro studies in rodents have provided evidence that DCC might function as a receptor for the axonal chemoattractant netrin-1. Inactivation of the murine Dcc gene caused defects in axonal projections that are similar to those observed in netrin-1-deficient mice but did not affect growth, differentiation, morphogenesis or tumorigenesis in mouse intestine. These observations fail to support a tumour-suppressor function for Dcc, but are consistent with the hypothesis that DCC is a component of a receptor for netrin-1.

Original language	English
Pages (from-to)	796-804
Number of pages	9
Journal	Nature
Volume	386
Issue number	6627
DOIs	https://doi.org/10.1038/386796a0
State	Published - Apr 24 1997

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Fazeli, A., Dickinson, S. L., Hermiston, M. L., Tighe, R. V., Steen, R. G., Small, C. G., Stoeckli, E. T., Keino-Masu, K., Masu, M., Rayburn, H., Simons, J., Bronson, R. T., Gordon, J. I., Tessier-Lavigne, M., & Weinberg, R. A. (1997). Phenotype of mice lacking functional Deleted in colorectal cancer (Dcc) gene. Nature, 386(6627), 796-804. https://doi.org/10.1038/386796a0

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title = "Phenotype of mice lacking functional Deleted in colorectal cancer (Dcc) gene",

abstract = "The DCC (Deleted in colorectal cancer) gene was first identified us u candidate for a tumour-suppressor gene on human chromosome 18q. Moro recently, in vitro studies in rodents have provided evidence that DCC might function as a receptor for the axonal chemoattractant netrin-1. Inactivation of the murine Dcc gene caused defects in axonal projections that are similar to those observed in netrin-1-deficient mice but did not affect growth, differentiation, morphogenesis or tumorigenesis in mouse intestine. These observations fail to support a tumour-suppressor function for Dcc, but are consistent with the hypothesis that DCC is a component of a receptor for netrin-1.",

author = "Amin Fazeli and Dickinson, \{Stephanie L.\} and Hermiston, \{Michelle L.\} and Tighe, \{Robert V.\} and Steen, \{Robert G.\} and Small, \{Clayton G.\} and Stoeckli, \{Esther T.\} and Kazuko Keino-Masu and Masayuki Masu and Helen Rayburn and Jonathan Simons and Bronson, \{Roderick T.\} and Gordon, \{Jeffrey I.\} and Marc Tessier-Lavigne and Weinberg, \{Robert A.\}",

year = "1997",

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doi = "10.1038/386796a0",

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AU - Fazeli, Amin

AU - Dickinson, Stephanie L.

AU - Hermiston, Michelle L.

AU - Tighe, Robert V.

AU - Steen, Robert G.

AU - Small, Clayton G.

AU - Stoeckli, Esther T.

AU - Keino-Masu, Kazuko

AU - Masu, Masayuki

AU - Rayburn, Helen

AU - Simons, Jonathan

AU - Bronson, Roderick T.

AU - Gordon, Jeffrey I.

AU - Tessier-Lavigne, Marc

AU - Weinberg, Robert A.

PY - 1997/4/24

Y1 - 1997/4/24

N2 - The DCC (Deleted in colorectal cancer) gene was first identified us u candidate for a tumour-suppressor gene on human chromosome 18q. Moro recently, in vitro studies in rodents have provided evidence that DCC might function as a receptor for the axonal chemoattractant netrin-1. Inactivation of the murine Dcc gene caused defects in axonal projections that are similar to those observed in netrin-1-deficient mice but did not affect growth, differentiation, morphogenesis or tumorigenesis in mouse intestine. These observations fail to support a tumour-suppressor function for Dcc, but are consistent with the hypothesis that DCC is a component of a receptor for netrin-1.

AB - The DCC (Deleted in colorectal cancer) gene was first identified us u candidate for a tumour-suppressor gene on human chromosome 18q. Moro recently, in vitro studies in rodents have provided evidence that DCC might function as a receptor for the axonal chemoattractant netrin-1. Inactivation of the murine Dcc gene caused defects in axonal projections that are similar to those observed in netrin-1-deficient mice but did not affect growth, differentiation, morphogenesis or tumorigenesis in mouse intestine. These observations fail to support a tumour-suppressor function for Dcc, but are consistent with the hypothesis that DCC is a component of a receptor for netrin-1.

UR - https://www.scopus.com/pages/publications/0030995125

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DO - 10.1038/386796a0

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VL - 386

SP - 796

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JO - Nature

JF - Nature

IS - 6627

ER -

Phenotype of mice lacking functional Deleted in colorectal cancer (Dcc) gene

Abstract

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