Phenotype of mice lacking functional Deleted in colorectal cancer (Dcc) gene

Amin Fazeli, Stephanie L. Dickinson, Michelle L. Hermiston, Robert V. Tighe, Robert G. Steen, Clayton G. Small, Esther T. Stoeckli, Kazuko Keino-Masu, Masayuki Masu, Helen Rayburn, Jonathan Simons, Roderick T. Bronson, Jeffrey I. Gordon, Marc Tessier-Lavigne, Robert A. Weinberg

Research output: Contribution to journalArticlepeer-review

661 Scopus citations


The DCC (Deleted in colorectal cancer) gene was first identified us u candidate for a tumour-suppressor gene on human chromosome 18q. Moro recently, in vitro studies in rodents have provided evidence that DCC might function as a receptor for the axonal chemoattractant netrin-1. Inactivation of the murine Dcc gene caused defects in axonal projections that are similar to those observed in netrin-1-deficient mice but did not affect growth, differentiation, morphogenesis or tumorigenesis in mouse intestine. These observations fail to support a tumour-suppressor function for Dcc, but are consistent with the hypothesis that DCC is a component of a receptor for netrin-1.

Original languageEnglish
Pages (from-to)796-804
Number of pages9
Issue number6627
StatePublished - Apr 24 1997


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