Phenotype of mice lacking functional Deleted in colorectal cancer (Dcc) gene

Amin Fazeli; Stephanie L. Dickinson; Michelle L. Hermiston; Robert V. Tighe; Robert G. Steen; Clayton G. Small; Esther T. Stoeckli; Kazuko Keino-Masu; Masayuki Masu; Helen Rayburn; Jonathan Simons; Roderick T. Bronson; Jeffrey I. Gordon; Marc Tessier-Lavigne; Robert A. Weinberg

doi:10.1038/386796a0

Phenotype of mice lacking functional Deleted in colorectal cancer (Dcc) gene

Amin Fazeli, Stephanie L. Dickinson, Michelle L. Hermiston, Robert V. Tighe, Robert G. Steen, Clayton G. Small, Esther T. Stoeckli, Kazuko Keino-Masu, Masayuki Masu, Helen Rayburn, Jonathan Simons, Roderick T. Bronson, Jeffrey I. Gordon, Marc Tessier-Lavigne, Robert A. Weinberg

Research output: Contribution to journal › Article › peer-review

661 Scopus citations

Abstract

The DCC (Deleted in colorectal cancer) gene was first identified us u candidate for a tumour-suppressor gene on human chromosome 18q. Moro recently, in vitro studies in rodents have provided evidence that DCC might function as a receptor for the axonal chemoattractant netrin-1. Inactivation of the murine Dcc gene caused defects in axonal projections that are similar to those observed in netrin-1-deficient mice but did not affect growth, differentiation, morphogenesis or tumorigenesis in mouse intestine. These observations fail to support a tumour-suppressor function for Dcc, but are consistent with the hypothesis that DCC is a component of a receptor for netrin-1.

Original language	English
Pages (from-to)	796-804
Number of pages	9
Journal	Nature
Volume	386
Issue number	6627
DOIs	https://doi.org/10.1038/386796a0
State	Published - Apr 24 1997

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Fazeli, A., Dickinson, S. L., Hermiston, M. L., Tighe, R. V., Steen, R. G., Small, C. G., Stoeckli, E. T., Keino-Masu, K., Masu, M., Rayburn, H., Simons, J., Bronson, R. T., Gordon, J. I., Tessier-Lavigne, M., & Weinberg, R. A. (1997). Phenotype of mice lacking functional Deleted in colorectal cancer (Dcc) gene. Nature, 386(6627), 796-804. https://doi.org/10.1038/386796a0

Fazeli, Amin ; Dickinson, Stephanie L. ; Hermiston, Michelle L. ; Tighe, Robert V. ; Steen, Robert G. ; Small, Clayton G. ; Stoeckli, Esther T. ; Keino-Masu, Kazuko ; Masu, Masayuki ; Rayburn, Helen ; Simons, Jonathan ; Bronson, Roderick T. ; Gordon, Jeffrey I. ; Tessier-Lavigne, Marc ; Weinberg, Robert A. / Phenotype of mice lacking functional Deleted in colorectal cancer (Dcc) gene. In: Nature. 1997 ; Vol. 386, No. 6627. pp. 796-804.

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title = "Phenotype of mice lacking functional Deleted in colorectal cancer (Dcc) gene",

abstract = "The DCC (Deleted in colorectal cancer) gene was first identified us u candidate for a tumour-suppressor gene on human chromosome 18q. Moro recently, in vitro studies in rodents have provided evidence that DCC might function as a receptor for the axonal chemoattractant netrin-1. Inactivation of the murine Dcc gene caused defects in axonal projections that are similar to those observed in netrin-1-deficient mice but did not affect growth, differentiation, morphogenesis or tumorigenesis in mouse intestine. These observations fail to support a tumour-suppressor function for Dcc, but are consistent with the hypothesis that DCC is a component of a receptor for netrin-1.",

author = "Amin Fazeli and Dickinson, {Stephanie L.} and Hermiston, {Michelle L.} and Tighe, {Robert V.} and Steen, {Robert G.} and Small, {Clayton G.} and Stoeckli, {Esther T.} and Kazuko Keino-Masu and Masayuki Masu and Helen Rayburn and Jonathan Simons and Bronson, {Roderick T.} and Gordon, {Jeffrey I.} and Marc Tessier-Lavigne and Weinberg, {Robert A.}",

year = "1997",

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day = "24",

doi = "10.1038/386796a0",

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volume = "386",

pages = "796--804",

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Phenotype of mice lacking functional Deleted in colorectal cancer (Dcc) gene. / Fazeli, Amin; Dickinson, Stephanie L.; Hermiston, Michelle L.; Tighe, Robert V.; Steen, Robert G.; Small, Clayton G.; Stoeckli, Esther T.; Keino-Masu, Kazuko; Masu, Masayuki; Rayburn, Helen; Simons, Jonathan; Bronson, Roderick T.; Gordon, Jeffrey I.; Tessier-Lavigne, Marc; Weinberg, Robert A.

In: Nature, Vol. 386, No. 6627, 24.04.1997, p. 796-804.

Research output: Contribution to journal › Article › peer-review

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T1 - Phenotype of mice lacking functional Deleted in colorectal cancer (Dcc) gene

AU - Fazeli, Amin

AU - Dickinson, Stephanie L.

AU - Hermiston, Michelle L.

AU - Tighe, Robert V.

AU - Steen, Robert G.

AU - Small, Clayton G.

AU - Stoeckli, Esther T.

AU - Keino-Masu, Kazuko

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AU - Rayburn, Helen

AU - Simons, Jonathan

AU - Bronson, Roderick T.

AU - Gordon, Jeffrey I.

AU - Tessier-Lavigne, Marc

AU - Weinberg, Robert A.

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Phenotype of mice lacking functional Deleted in colorectal cancer (Dcc) gene

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