Phase I/II trial of accelerated fractionation in brain metastases RTOG 85-28

William T. Sause, Charles Scott, Robert Krisch, Marvin Rotman, Patricia K. Sneed, Nora Janjan, Lawrence Davis, Walter Curran, Kwang N. Choi, Hosny Selim, Mohammed Mohiuddin, Perry Grigsby

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92 Scopus citations


Purpose: Radiation Therapy Oncology Group 85-28 represents a Phase I/II trial of accelerated fractionation in patients with brain metastases. Methods and Materials: Patients entered had controlled or absent primary with metastases other than brain which were stable or only brain metastases with the primary uncontrolled. Karnosfky status was required to be greater than 60. Patients received 1.6 Gy twice daily separated by 4-8 hr delivered 5 days a week. The entire brain was treated to 32.0 Gy and the boost dose escalated from 16.0 Gy to 22.40 Gy and subsequently 32.00 Gy and 42.40 Gy. Results: We observed no undue toxicity with escalating dose of irradiation. An incremental, although not statistically significant improvement in survival was noted with escalating doses. Median survival ranged from 4.2 months to 6.4 months with escalating dose of irradiation. Median survival also increased in patients with controlled primary tumors, non-lung primaries and solitary metastasis. Conclusion: The incremental improvement in survival in patients with good prognostic factors appeared encouraging. The Radiation Therapy Oncology Group will test the 54.4 Gy study against 30 Gy in 2 weeks in a Phase III trial based on the results of this trial.

Original languageEnglish
Pages (from-to)653-657
Number of pages5
JournalInternational journal of radiation oncology, biology, physics
Issue number4
StatePublished - Jul 15 1993


  • Brain metastases
  • Radiation therapy


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