Phase cancellation system for tumor imaging using targeted fluorescent contrast agents

Yu Chen, Lanlan Zhou, Chenpeng Mu, Xavier Intes, Samuel Achilefu, Britton Chance

Research output: Contribution to journalConference articlepeer-review


Recent developments in receptor specific targeting fluorescent contrast agents can give tumor/tissue contrasts in the excess of 10, and are capable of selectively labeling various pre-cancer/cancer signatures to enhance the sensitivity and specificity of cancer detection [reference: Weissleder et al, Achilefu et al]. We have developed a novel imaging system for fast and accurate localization of fluorescent contrast agent labeled tumor embedded several centimeters inside the highly scattering medium mimicking breast tissue using the phased cancellation configuration (0° and 180° source-pair) with a goniometric probe. Phantom tests and intratumor injection of fluorescent dye, Indocyanine Green (ICG), have demonstrated the capability of two-dimensional localization of tumor labeled with fluorescent contrast agents about 3.0 cm deep within several millimeters error range. The accuracy of the localization suggests that this system would be helpful to guide the clinical fine-needle biopsy for early detection of breast cancer.

Original languageEnglish
Pages (from-to)22-29
Number of pages8
JournalProceedings of SPIE - The International Society for Optical Engineering
StatePublished - 2002
Eventoptics in Health Care and Biomedical Optics: Diagnostics and Treatment - Shanghai, China
Duration: Oct 15 2002Oct 18 2002


  • Contrast agents
  • Fluorescence
  • Near-infrared
  • Phased array
  • Tumor detection


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