Phase-amplitude coupling between neuronal wideband low-frequency oscillations and broadband gamma activity

Tao Xie, Zehan Wu, Liang Chen, Xiangyang Zhu, Xinjun Sheng, Peter Brunner

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Phase-amplitude coupling (PAC) between the phase of low-frequency oscillations and the power of high-frequency activity plays a functional role in neuronal computation and information transfer. Traditional Hilbert transform-based PAC methods assume that neuronal activity is narrowband, sinusoidal, and sustained. However, natural neuronal signals often violate these three assumptions, creating a potential confound for the interpretation of PAC results. In this study, we present a new method, called Tau-Modulation, that does not require these assumptions to be met. We use this method to identify task-relevant neuronal networks in human electrocorticographic signals. Our results show that Tau-Modulation can identify these networks and characterize the strength and frequency of wideband low-frequency coupling with broadband gamma activity. Thus, Tau-Modulation might provide for a robust approach to analyzing neuronal signals and pave the way for new insights on brain functions.

Original languageEnglish
Title of host publication2021 10th International IEEE/EMBS Conference on Neural Engineering, NER 2021
PublisherIEEE Computer Society
Pages95-98
Number of pages4
ISBN (Electronic)9781728143378
DOIs
StatePublished - May 4 2021
Event10th International IEEE/EMBS Conference on Neural Engineering, NER 2021 - Virtual, Online, Italy
Duration: May 4 2021May 6 2021

Publication series

NameInternational IEEE/EMBS Conference on Neural Engineering, NER
Volume2021-May
ISSN (Print)1948-3546
ISSN (Electronic)1948-3554

Conference

Conference10th International IEEE/EMBS Conference on Neural Engineering, NER 2021
Country/TerritoryItaly
CityVirtual, Online
Period05/4/2105/6/21

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