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Phase 1/1b open-label, dose-escalation study of fruquintinib in patients with advanced solid tumors in the United States
Andrea Wang-Gillam
, William Schelman
, Stacey Ukrainskyj
, Caly Chien
, Martha Gonzalez
, Zhao Yang
, Marek Kania
, Heather Yeckes-Rodin
Section of Medical Oncology
Institute of Clinical and Translational Sciences (ICTS)
Bursky Center for Human Immunology & Immunotherapy Programs (CHiiPs)
Section of Molecular Oncology & Developmental Therapeutics
Siteman Cancer Center
Research output
:
Contribution to journal
›
Article
›
peer-review
11
Scopus citations
Overview
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Keyphrases
United States
100%
Dose-escalation Study
100%
Advanced Solid Tumors
100%
Recommended Phase 2 Dose
100%
Fruquintinib
100%
Dose-limiting Toxicity
50%
Pharmacokinetics
50%
State Patient
50%
Hypertension
25%
China
25%
Expansion Cohort
25%
Dose Expansion
25%
Dose Escalation
25%
Safety Profile
25%
Steady State
25%
Partial Response
25%
Systemic Therapy
25%
Treatment-related Adverse Events
25%
Multiple Dose
25%
Tolerability
25%
Once-daily
25%
Pharmacokinetic Profile
25%
Anticancer Activity
25%
Systemic Exposure
25%
Dose Finding
25%
3 + 3 Design
25%
Peak Plasma Concentration
25%
Study in China
25%
Pharmacology, Toxicology and Pharmaceutical Science
Solid Malignant Neoplasm
100%
Fruquintinib
100%
Pharmacokinetics
75%
Adverse Event
25%
Tolerability
25%