Phase 1 and pharmacokinetic study of weekly docosahexaenoic acid-paclitaxel, Taxoprexin®, in resistant solid tumor malignancies

Paula M. Fracasso, Joel Picus, Jonathan D. Wildi, Sherry A. Goodner, Allison N. Creekmore, Feng Gao, Ramaswamy Govindan, Matthew J. Ellis, Benjamin R. Tan, Gerald P. Linette, Chauhwei J. Fu, Helen S. Pentikis, Stephen C. Zumbrun, Merrill J. Egorin, Robert E. Bellet

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43 Scopus citations

Abstract

Purpose: To determine the maximum tolerated dose, dose-limiting toxicity (DLT), and pharmacokinetics of weekly docosahexaenoic acid-paclitaxel (DHA-paclitaxel), a taxane fatty acid conjugate. Experimental design: Docosahexaenoic acid-paclitaxel was administered by 2-hour i.v. infusion weekly for three out of four weeks. DHA-paclitaxel 200 mg/m2 was dose escalated by 100 mg/m2 per cohort to 600 mg/m2. Blood samples for pharmacokinetics of DHA-paclitaxel and paclitaxel derived from DHA-paclitaxel were collected. Results: Twenty-one patients received 42 cycles of treatment over five dose levels. Grade 3/4 neutropenia occurred in five patients but was not dose limiting. Grade 3 hyperbilirubinemia, a DLT, and grade 1 sensory neuropathy occurred at the highest dose level. PK analyses demonstrated dose proportional C max and AUC0-24. Limited accumulation of DHA-paclitaxel or paclitaxel occurred with weekly treatment. Increased DHA-paclitaxel and paclitaxel AUC0-24 were associated with increased neutropenia. Of the 19 patients evaluable for response, three patients with esophageal, melanoma and colon carcinoma had stable disease for 11, 16, and 17 weeks, respectively. Conclusion: Docosahexaenoic acid-paclitaxel administered weekly to a maximum dose of 600 mg/m2 was well-tolerated. The slow release of paclitaxel from DHA-paclitaxel and the weekly schedule approximates continuous infusion paclitaxel which may be more active than every 3 week or weekly taxanes.

Original languageEnglish
Pages (from-to)451-458
Number of pages8
JournalCancer Chemotherapy and Pharmacology
Volume63
Issue number3
DOIs
StatePublished - Feb 1 2009

Keywords

  • DHA-paclitaxel
  • Phase 1
  • Taxoprexin

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    Fracasso, P. M., Picus, J., Wildi, J. D., Goodner, S. A., Creekmore, A. N., Gao, F., Govindan, R., Ellis, M. J., Tan, B. R., Linette, G. P., Fu, C. J., Pentikis, H. S., Zumbrun, S. C., Egorin, M. J., & Bellet, R. E. (2009). Phase 1 and pharmacokinetic study of weekly docosahexaenoic acid-paclitaxel, Taxoprexin®, in resistant solid tumor malignancies. Cancer Chemotherapy and Pharmacology, 63(3), 451-458. https://doi.org/10.1007/s00280-008-0756-0