Pharmacology research on PXR as a potential target in screening bioactive components of Chinese material medica

Yu Guang Wang; Xian Xie Zhang; Han Li; Bei Bei Lu; Jian Ming Zhou; Hao Sheng Liu; Dong Hua Hu; Tao Zhou; Ya Xin Zhang; Zeng Chun Ma; Qian De Liang; Xiang Lin Tang; Cheng Rong Xiao; Hong Ling Tan; Yue Gao

doi:10.4268/cjcmm20151721

Pharmacology research on PXR as a potential target in screening bioactive components of Chinese material medica

Yu Guang Wang, Xian Xie Zhang, Han Li, Bei Bei Lu, Jian Ming Zhou, Hao Sheng Liu, Dong Hua Hu, Tao Zhou, Ya Xin Zhang, Zeng Chun Ma, Qian De Liang, Xiang Lin Tang, Cheng Rong Xiao, Hong Ling Tan, Yue Gao

Division of Cancer Biology

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Pregnane X receptor (PXR) is key transcription factors which mainly regulate the expression of CYP3A genes. At the molecular level, PXR has been revealed the protection mechanism of the body against xenochemicals and a major mode of the drug-drug interactions. Besides playing an important role in drug metabolism and interactions, PXR and its target genes also play an important role in maintaining normal physiological function and homeostasis. Therefore, it is necessary to study the regulation of PXR and its related pharmacological effects of TCM and natural products, and to provide new clues for the new pharmacological pathway.

Original language	English
Pages (from-to)	3444-3449
Number of pages	6
Journal	Zhongguo Zhongyao Zazhi
Volume	40
Issue number	17
DOIs	https://doi.org/10.4268/cjcmm20151721
State	Published - Sep 2015

Keywords

CYP3A
Lithocholic acid
Pregnane X receptor
Ulcerative colitis

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10.4268/cjcmm20151721

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Wang, Y. G., Zhang, X. X., Li, H., Lu, B. B., Zhou, J. M., Liu, H. S., Hu, D. H., Zhou, T., Zhang, Y. X., Ma, Z. C., Liang, Q. D., Tang, X. L., Xiao, C. R., Tan, H. L., & Gao, Y. (2015). Pharmacology research on PXR as a potential target in screening bioactive components of Chinese material medica. Zhongguo Zhongyao Zazhi, 40(17), 3444-3449. https://doi.org/10.4268/cjcmm20151721

@article{20523f1a48da4f06a75ec3eb27d31a74,

title = "Pharmacology research on PXR as a potential target in screening bioactive components of Chinese material medica",

abstract = "Pregnane X receptor (PXR) is key transcription factors which mainly regulate the expression of CYP3A genes. At the molecular level, PXR has been revealed the protection mechanism of the body against xenochemicals and a major mode of the drug-drug interactions. Besides playing an important role in drug metabolism and interactions, PXR and its target genes also play an important role in maintaining normal physiological function and homeostasis. Therefore, it is necessary to study the regulation of PXR and its related pharmacological effects of TCM and natural products, and to provide new clues for the new pharmacological pathway.",

keywords = "CYP3A, Lithocholic acid, Pregnane X receptor, Ulcerative colitis",

author = "Wang, {Yu Guang} and Zhang, {Xian Xie} and Han Li and Lu, {Bei Bei} and Zhou, {Jian Ming} and Liu, {Hao Sheng} and Hu, {Dong Hua} and Tao Zhou and Zhang, {Ya Xin} and Ma, {Zeng Chun} and Liang, {Qian De} and Tang, {Xiang Lin} and Xiao, {Cheng Rong} and Tan, {Hong Ling} and Yue Gao",

year = "2015",

month = sep,

doi = "10.4268/cjcmm20151721",

language = "English",

volume = "40",

pages = "3444--3449",

journal = "Zhongguo Zhongyao Zazhi",

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TY - JOUR

T1 - Pharmacology research on PXR as a potential target in screening bioactive components of Chinese material medica

AU - Wang, Yu Guang

AU - Zhang, Xian Xie

AU - Li, Han

AU - Lu, Bei Bei

AU - Zhou, Jian Ming

AU - Liu, Hao Sheng

AU - Hu, Dong Hua

AU - Zhou, Tao

AU - Zhang, Ya Xin

AU - Ma, Zeng Chun

AU - Liang, Qian De

AU - Tang, Xiang Lin

AU - Xiao, Cheng Rong

AU - Tan, Hong Ling

AU - Gao, Yue

PY - 2015/9

Y1 - 2015/9

N2 - Pregnane X receptor (PXR) is key transcription factors which mainly regulate the expression of CYP3A genes. At the molecular level, PXR has been revealed the protection mechanism of the body against xenochemicals and a major mode of the drug-drug interactions. Besides playing an important role in drug metabolism and interactions, PXR and its target genes also play an important role in maintaining normal physiological function and homeostasis. Therefore, it is necessary to study the regulation of PXR and its related pharmacological effects of TCM and natural products, and to provide new clues for the new pharmacological pathway.

AB - Pregnane X receptor (PXR) is key transcription factors which mainly regulate the expression of CYP3A genes. At the molecular level, PXR has been revealed the protection mechanism of the body against xenochemicals and a major mode of the drug-drug interactions. Besides playing an important role in drug metabolism and interactions, PXR and its target genes also play an important role in maintaining normal physiological function and homeostasis. Therefore, it is necessary to study the regulation of PXR and its related pharmacological effects of TCM and natural products, and to provide new clues for the new pharmacological pathway.

KW - CYP3A

KW - Lithocholic acid

KW - Pregnane X receptor

KW - Ulcerative colitis

UR - http://www.scopus.com/inward/record.url?scp=84946737173&partnerID=8YFLogxK

U2 - 10.4268/cjcmm20151721

DO - 10.4268/cjcmm20151721

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AN - SCOPUS:84946737173

SN - 1001-5302

VL - 40

SP - 3444

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JO - Zhongguo Zhongyao Zazhi

JF - Zhongguo Zhongyao Zazhi

IS - 17

ER -

Pharmacology research on PXR as a potential target in screening bioactive components of Chinese material medica

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Keywords

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