Pharmacology of local anesthetics: Mechanism of action and pharmacokinetics

Jessica Bauerle; Zhiling Xiong

doi:10.1017/CBO9781139584005.047

Pharmacology of local anesthetics: Mechanism of action and pharmacokinetics

Jessica Bauerle, Zhiling Xiong

Division of Pediatric Anesthesiology

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Local anesthetics result in loss of sensation in the targeted area by stopping propagation of nerve impulses. In 1884, cocaine was the first local anesthetic discovered, but given its addictive and dependent properties, it was not a reasonable and routine clinical option. Procaine was then introduced in 1905, and lidocaine in 1944.

Original language	English
Title of host publication	Essential Clinical Anesthesia Review
Subtitle of host publication	Keywords, Questions and Answers for the Boards
Publisher	Cambridge University Press
Pages	159-160
Number of pages	2
ISBN (Electronic)	9781139584005
ISBN (Print)	9781107681309
DOIs	https://doi.org/10.1017/CBO9781139584005.047
State	Published - Jan 1 2015

Keywords

Local anesthesia potency: Lipid solubility
Local anesthetics
Local anesthetics: Mechanism of action
Local anesthetics: Metabolism
Local anesthetics: Toxicity

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10.1017/CBO9781139584005.047

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Pharmacology of local anesthetics: Mechanism of action and pharmacokinetics

Abstract

Keywords

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