Pharmacology and pharmacogenetics of warfarin and other coumarins when used with supplements

Brian F. Gage, Paul E. Milligan

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

To summarize, warfarin is the drug mostly commonly reported to interact with supplements. However, reporting of interactions is sporadic and sometimes contradictory. For example, Ginseng may increase the clearance of warfarin, but trial evidence is conflicting. Co-enzyme Q10 and Ginkgo biloba may not interfere with warfarin activity significantly, but further study is necessary. St. John's wort likely increases hepatic clearance of warfarin and phenprocoumon, thereby decreasing the anti-coagulant effect of these coumarins.

Original languageEnglish
Pages (from-to)55-59
Number of pages5
JournalThrombosis Research
Volume117
Issue number1-2
DOIs
StatePublished - Nov 18 2005

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