Pharmacological differentiation of the effects of co-activation of β-adrenergic and metabotropic glutamate receptors in rat hippocampus

Robert W. Gereau IV, Danny G. Winder, P. Jeffrey Conn

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Activation of metabotropic glutamate receptors (mGluRs) can potentiate the cAMP response elicited by activation of β-adrenergic receptors (βARs) in the hippocampus. We have shown that co-activation of mGluRs and βARs induces both an acute depression of excitatory synaptic transmission and a long-lasting excitation of CA1 pyramidal cells. However, these studies were performed using a non-selective mGluR agonist. We have now used subtype selective mGluR agonists, and report that while the acute depression of transmission exhibits a pharmacology consistent with mediation by this mGluR subtype, the lasting excitation of CA1 pyramidal cells may be mediated by an interaction between βARs and mGluRs that are coupled to phosphoinositide hydrolysis.

Original languageEnglish
Pages (from-to)119-122
Number of pages4
JournalNeuroscience Letters
Volume186
Issue number2-3
DOIs
StatePublished - Feb 17 1995
Externally publishedYes

Keywords

  • (2,1′,2′,3′)-2-(Dicarboxycylopropyl)glycine (DCG-IV)
  • 3,5-Dihydroxyphenylglycine
  • Adenyl cyclase
  • Metabotropic glutamate receptor
  • Phosphoinositide hydrolysis
  • β-Adrenergic receptor

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