TY - JOUR
T1 - Pharmacological differentiation of the effects of co-activation of β-adrenergic and metabotropic glutamate receptors in rat hippocampus
AU - Gereau IV, Robert W.
AU - Winder, Danny G.
AU - Conn, P. Jeffrey
N1 - Funding Information:
The authors wish to thank Dr. H. Shinozaki for the generous gift of DCG-IV. This work was supported by NIH grants NS-28405 and NS-31373 and a grant from the Council for Tobacco Research. RWG is a predoctoral fellow of the Howard Hughes Medical Institute. DGW is supported by an NIH predoctoral NRSA.
PY - 1995/2/17
Y1 - 1995/2/17
N2 - Activation of metabotropic glutamate receptors (mGluRs) can potentiate the cAMP response elicited by activation of β-adrenergic receptors (βARs) in the hippocampus. We have shown that co-activation of mGluRs and βARs induces both an acute depression of excitatory synaptic transmission and a long-lasting excitation of CA1 pyramidal cells. However, these studies were performed using a non-selective mGluR agonist. We have now used subtype selective mGluR agonists, and report that while the acute depression of transmission exhibits a pharmacology consistent with mediation by this mGluR subtype, the lasting excitation of CA1 pyramidal cells may be mediated by an interaction between βARs and mGluRs that are coupled to phosphoinositide hydrolysis.
AB - Activation of metabotropic glutamate receptors (mGluRs) can potentiate the cAMP response elicited by activation of β-adrenergic receptors (βARs) in the hippocampus. We have shown that co-activation of mGluRs and βARs induces both an acute depression of excitatory synaptic transmission and a long-lasting excitation of CA1 pyramidal cells. However, these studies were performed using a non-selective mGluR agonist. We have now used subtype selective mGluR agonists, and report that while the acute depression of transmission exhibits a pharmacology consistent with mediation by this mGluR subtype, the lasting excitation of CA1 pyramidal cells may be mediated by an interaction between βARs and mGluRs that are coupled to phosphoinositide hydrolysis.
KW - (2,1′,2′,3′)-2-(Dicarboxycylopropyl)glycine (DCG-IV)
KW - 3,5-Dihydroxyphenylglycine
KW - Adenyl cyclase
KW - Metabotropic glutamate receptor
KW - Phosphoinositide hydrolysis
KW - β-Adrenergic receptor
UR - http://www.scopus.com/inward/record.url?scp=0028910308&partnerID=8YFLogxK
U2 - 10.1016/0304-3940(95)11300-L
DO - 10.1016/0304-3940(95)11300-L
M3 - Article
C2 - 7777178
AN - SCOPUS:0028910308
VL - 186
SP - 119
EP - 122
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 2-3
ER -