Pharmacokinetics of two per cent rectal methohexitone in children

R. B. Forbes, K. L. Croskey, D. L. Dull, D. J. Murray, J. B. Dillman, K. Murphy

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Rectal methohexitone is a safe, pleasant technique for the induction of anaesthesia in young children and use of a ten per cent solution results in a rapid, reliable onset of sleep. Some investigators have reported that 15 mg·kg-1 of a less concentrated solution was as effective as 25 mg·kg-1 ten per cent methohexitone for induction anaesthesia and that use of a two per cent solution resulted in higher peak plasma methohexitone concentrations. Because changes in the concentration of the methohexitone solution alter its pharmacokinetics, the optimal dose of two per cent methohexitone for induction of anaesthesia has not been determined. The purpose of this investigation was to compare the effectiveness of plasma methohexitone concentrations achieved following rectal administration of four different doses of two per cent methohexitone.

Original languageEnglish
Pages (from-to)S 138-S139
JournalCanadian Journal of Anaesthesia
Issue number3 II
StatePublished - Jan 1 1988

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    Forbes, R. B., Croskey, K. L., Dull, D. L., Murray, D. J., Dillman, J. B., & Murphy, K. (1988). Pharmacokinetics of two per cent rectal methohexitone in children. Canadian Journal of Anaesthesia, 35(3 II), S 138-S139.