Pharmacokinetic principles in the inner ear: Influence of drug properties on intratympanic applications

Alec N. Salt, Stefan K. Plontke

Research output: Contribution to journalReview articlepeer-review

67 Scopus citations

Abstract

Local drug delivery to the ear has gained wide clinical acceptance, with the choice of drug and application protocol in humans largely empirically-derived. Here, we review the pharmacokinetics underlying local therapy of the ear using the drugs commonly used in clinical practice as examples. Based on molecular properties and perilymph measurements interpreted through computer simulations we now better understand the principles underlying entry and distribution of these and other drugs in the ear. From our analysis, we have determined that dexamethasone-phosphate, a pro-drug widely-used clinically, has molecular and pharmacokinetic properties that make it ill-suited for use as a local therapy for hearing disorders. This polar form of dexamethasone, used as a more soluble agent in intravenous preparations, passes less readily through lipid membranes, such as those of the epithelia restricting entry at the round window membrane and stapes. Once within the inner ear, dexamethasone-phosphate is cleaved to the active form, dexamethasone, which is less polar, passes more readily through lipid membranes of the blood-perilymph barrier and is rapidly eliminated from perilymph without distributing to apical cochlear regions. Dexamethasone-phosphate therefore provides only a brief exposure of the basal regions of the cochlea to active drug. Other steroids, such as triamcinolone-acetonide, exhibit pharmacokinetic properties more appropriate to the ear and merit more detailed consideration.

Original languageEnglish
Pages (from-to)28-40
Number of pages13
JournalHearing research
Volume368
DOIs
StatePublished - Oct 2018

Keywords

  • Drug delivery
  • Inner ear
  • Intracochlear
  • Intralabyrinthine
  • Oval window
  • Perilymph
  • Round window membrane

Fingerprint

Dive into the research topics of 'Pharmacokinetic principles in the inner ear: Influence of drug properties on intratympanic applications'. Together they form a unique fingerprint.

Cite this