Les limites pharmacocinétiques pour définir la dose adéquate de la supplementation en zinc

Translated title of the contribution: Pharmacokinetic considerations in zinc supplementation: Getting the dose right

Research output: Contribution to journalReview articlepeer-review


Studies on the efficacy of zinc supplementation in populations at risk for zinc deficiency are hampered by the lack of information on the proper dose and timing of such doses. These problems arise in part from the lack of adequate information derivedfrom pharmacokinetic (PK) studies, the usual source of such data for supplementation with drugs. Because endogenous zinc pools exist in tissues, standard PK studies provide inaccurate answers, and isotopie tracer studies in healthy subjects must be used to develop models of zinc kinetics. But these studies poorly estimate dose and timing of doses, and the results cannot be used to inform dosing in the zinc deficient patient. Thus, treatment of zinc deficiency in high risk populations has been empirical, and will continue to be so, until more reliable information on the kinetics of zinc supplementation are available.

Translated title of the contributionPharmacokinetic considerations in zinc supplementation: Getting the dose right
Original languageFrench
Pages (from-to)431-438
Number of pages8
JournalBulletin de l'Academie Nationale de Medecine
Issue number1-3
StatePublished - Jan 1 2017


  • Administration & dosage
  • Deficiency
  • Dietary supplements
  • Pharmacokinetics
  • Zinc
  • Zinc


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