Pharmacogenomics in rheumatoid arthritis

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

11 Scopus citations


Rheumatoid arthritis (RA) is a systemic inflammatory arthritis that leads to severe joint damage and is associated with high morbidity and mortality. Disease-modifying antirheumatic drugs (DMARDs) are the mainstay of treatment in RA. DMARDs not only relieve the clinical signs and symptoms of RA but also inhibit the radiographic progression of disease. Recently, a new class of disease-modifying medications, the biologic agents, has been added to the existing spectrum of DMARDs in RA. However, patients' response to these agents is not uniform, with considerable variability in both efficacy and toxicity. There are no reliable means of predicting an individual patient's response to a given DMARD prior to initiation of therapy. In this chapter, the current published literature on the pharmacogenomics of traditional DMARDs and the newer biologic DMARDs in RA is highlighted. Pharmacogenomics may help individualize drug therapy in patients with RA in the near future.

Original languageEnglish
Title of host publicationPharmacogenomics in Drug Discovery and Development
Subtitle of host publicationFrom Bench to Bedside
PublisherHumana Press
Number of pages23
ISBN (Print)9781588298874
StatePublished - 2008

Publication series

NameMethods in Molecular Biology
ISSN (Print)1064-3745


  • Azathioprine
  • Methotrexate
  • Pharmacogenetics
  • Polymorphisms
  • Rheumatoid arthritis
  • Sulfasalazine
  • Tumor necrosis factor antagonists


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