Abstract
Pharmacogenetics is the study of gene-drug interactions. In the post-Human Genome era, and with the realization that personal genotypes differ by millions of bases (gene polymorphisms), the application of genetics to explain interindividual differences in clinical drug response seems to offer great promise. Here, recent basic and translational developments in pharmacogenetic profiling of β-blocker response in heart failure are reviewed in the context of the possible consequences of such advances on drug development and clinical therapeutics.
Original language | English |
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Pages (from-to) | 295-302 |
Number of pages | 8 |
Journal | Translational Research |
Volume | 154 |
Issue number | 6 |
DOIs | |
State | Published - Dec 2009 |