TY - JOUR
T1 - Phagocytes
T2 - their protective activity and their genetic and acquired defects
AU - Daughaday, C. C.
AU - Douglas, S. D.
PY - 1976
Y1 - 1976
N2 - Two types of phagocytic cells participate in host defense against bacteria: PMNs and MNPs. Their normal functions include mechanisms for specific attachment, ingestion and killing of bacteria, and direct cellular mobility to bring them into an area of bacterial invasion. Acquired or genetic defects in any of these processes result in inadequate control of bacterial growth. Among disorders associated with acquired defects of phagocytes are: kwashiorkor, bacterial endocarditis, myelogenous leukemia, diabetes mellitus, systemic mycoses, advanced malignancy, and acute alcohol intoxication. Among disorders associated with genetic defects of phagocytes are: chronic granulomatous disease, familial lipochrome histiocytosis, Job syndrome, Chediak Higashi syndrome, lazy leukocyte syndrome and myeloperoxidase deficiency. The cellular phagocytic defects in these disorders are reviewed.
AB - Two types of phagocytic cells participate in host defense against bacteria: PMNs and MNPs. Their normal functions include mechanisms for specific attachment, ingestion and killing of bacteria, and direct cellular mobility to bring them into an area of bacterial invasion. Acquired or genetic defects in any of these processes result in inadequate control of bacterial growth. Among disorders associated with acquired defects of phagocytes are: kwashiorkor, bacterial endocarditis, myelogenous leukemia, diabetes mellitus, systemic mycoses, advanced malignancy, and acute alcohol intoxication. Among disorders associated with genetic defects of phagocytes are: chronic granulomatous disease, familial lipochrome histiocytosis, Job syndrome, Chediak Higashi syndrome, lazy leukocyte syndrome and myeloperoxidase deficiency. The cellular phagocytic defects in these disorders are reviewed.
UR - http://www.scopus.com/inward/record.url?scp=0017197757&partnerID=8YFLogxK
U2 - 10.3928/0090-4481-19760601-05
DO - 10.3928/0090-4481-19760601-05
M3 - Article
C2 - 179049
AN - SCOPUS:0017197757
SN - 0090-4481
VL - 5
SP - 10
EP - 25
JO - Pediatric annals
JF - Pediatric annals
IS - 6
ER -