PGC-1 coactivators: Inducible regulators of energy metabolism in health and disease

Brian N. Finck; Daniel P. Kelly

doi:10.1172/JCI27794

PGC-1 coactivators: Inducible regulators of energy metabolism in health and disease

Brian N. Finck, Daniel P. Kelly

Research output: Contribution to journal › Review article › peer-review

1212 Scopus citations

Abstract

Members of the PPARγ coactivator-1 (PGC-1) family of transcriptional coactivators serve as inducible coregulators of nuclear receptors in the control of cellular energy metabolic pathways. This Review focuses on the biologic and physiologic functions of the PGC-1 coactivators, with particular emphasis on striated muscle, liver, and other organ systems relevant to common diseases such as diabetes and heart failure.

Original language	English
Pages (from-to)	615-622
Number of pages	8
Journal	Journal of Clinical Investigation
Volume	116
Issue number	3
DOIs	https://doi.org/10.1172/JCI27794
State	Published - Mar 1 2006

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abstract = "Members of the PPARγ coactivator-1 (PGC-1) family of transcriptional coactivators serve as inducible coregulators of nuclear receptors in the control of cellular energy metabolic pathways. This Review focuses on the biologic and physiologic functions of the PGC-1 coactivators, with particular emphasis on striated muscle, liver, and other organ systems relevant to common diseases such as diabetes and heart failure.",

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PGC-1 coactivators: Inducible regulators of energy metabolism in health and disease

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