PGC-1 coactivators: Inducible regulators of energy metabolism in health and disease

Brian N. Finck, Daniel P. Kelly

Research output: Contribution to journalReview article

921 Scopus citations

Abstract

Members of the PPARγ coactivator-1 (PGC-1) family of transcriptional coactivators serve as inducible coregulators of nuclear receptors in the control of cellular energy metabolic pathways. This Review focuses on the biologic and physiologic functions of the PGC-1 coactivators, with particular emphasis on striated muscle, liver, and other organ systems relevant to common diseases such as diabetes and heart failure.

Original languageEnglish
Pages (from-to)615-622
Number of pages8
JournalJournal of Clinical Investigation
Volume116
Issue number3
DOIs
StatePublished - Mar 1 2006

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