PET/CT in Neuroendocrine Tumors: Evaluation of Receptor Status and Metabolism

Vikas Prasad, Valentina Ambrosini, Abass Alavi, Stefano Fanti, Richard P. Baum

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations


In-111 Octreoscan is considered the gold standard for imaging of neuroendocrine tumors (NET). However, in the absence of morphologic imaging correlation, the exact localisation of the tumor is often difficult. Also the sensitivity of PET imaging is more than Gamma camera (SPECT) imaging. Ga-68 labelled somatostatin analogs (SMS-R) are interesting radiopharmaceuticals for PET receptor imaging of NET. Some other radiopharmaceuticals e.g. F-18 DOPA can also be used to assess metabolism and functional status of NET. The importance of these radiopharmaceuticals, especially SMS-R increases in the absence of any specific biochemical marker or clinical parameter for follow-up of patients after therapy (eg peptide receptor radionuclide therapy, surgery, chemoembolisation, etc). New criteria based on molecular, metabolic and morphologic imaging needs to be developed for correct assessment of response to therapy for these slow-growing, solid tumors.

Original languageEnglish
Pages (from-to)351-375
Number of pages25
JournalPET Clinics
Issue number3
StatePublished - Jul 2007


  • F-18 DOPA
  • Ga-68
  • Neuroendocrine tumors
  • PET/CT
  • Somatostatin receptor imaging


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