PET Radiotracers for Imaging the Proliferative Status of Solid Tumors

Robert H. Mach, Farrokh Dehdashti, Kenneth T. Wheeler

Research output: Contribution to journalReview article

21 Scopus citations

Abstract

Two different strategies have been developed for imaging the proliferative status of solid tumors with the functional imaging technique, PET. The first strategy uses carbon-11 labeled thymidine, or more recently, fluorine-18 labeled thymidine analogs. These agents are a substrate for the enzyme thymidine kinase-1(TK-1) and provide a pulse label of the number of cells in S phase. The second method for imaging the proliferative status of a tumor uses radio-labeled ligands that bind to the sigma-2 receptor which has a 10-fold higher density in proliferating (P) tumor cells versus quiescent (Q) tumor cells. This article compares and contrasts the two different strategies for imaging the proliferative status of solid tumors, and describes the strengths and weaknesses of each approach.

Original languageEnglish
Pages (from-to)1-15
Number of pages15
JournalPET Clinics
Volume4
Issue number1
DOIs
StatePublished - Jan 1 2009

Keywords

  • Cell proliferation
  • PET imaging
  • Sigma-2 receptors
  • Thymidine Kinase-1
  • Thymidine analogs

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