PET in cerebrovascular disease

William J. Powers; Allyson R. Zazulia

doi:10.1016/j.cpet.2009.12.007

PET in cerebrovascular disease

William J. Powers, Allyson R. Zazulia

Research output: Contribution to journal › Review article › peer-review

31 Scopus citations

Abstract

Investigation of the interplay between the cerebral circulation and brain cellular function is fundamental to understanding both the pathophysiology and treatment of stroke. At present, PET is the only technique that provides accurate, quantitative in vivo regional measurements of both cerebral circulation and cellular metabolism in human subjects. This article reviews normal human cerebral blood flow and metabolism, and human PET studies of ischemic stroke, carotid artery disease, vascular dementia, intracerebral hemorrhage, and aneurysmal subarachnoid hemorrhage, and discusses how these studies have added to the understanding of the pathophysiology of human cerebrovascular disease.

Original language	English
Pages (from-to)	83-106
Number of pages	24
Journal	PET Clinics
Volume	5
Issue number	1
DOIs	https://doi.org/10.1016/j.cpet.2009.12.007
State	Published - Jan 2010

Keywords

Cerebral blood flow
Cerebral hemodynamics
Cerebral metabolism
Cerebrovascular disease
Positron emission tomography
Vascular dementia

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10.1016/j.cpet.2009.12.007

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abstract = "Investigation of the interplay between the cerebral circulation and brain cellular function is fundamental to understanding both the pathophysiology and treatment of stroke. At present, PET is the only technique that provides accurate, quantitative in vivo regional measurements of both cerebral circulation and cellular metabolism in human subjects. This article reviews normal human cerebral blood flow and metabolism, and human PET studies of ischemic stroke, carotid artery disease, vascular dementia, intracerebral hemorrhage, and aneurysmal subarachnoid hemorrhage, and discusses how these studies have added to the understanding of the pathophysiology of human cerebrovascular disease.",

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AU - Zazulia, Allyson R.

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AB - Investigation of the interplay between the cerebral circulation and brain cellular function is fundamental to understanding both the pathophysiology and treatment of stroke. At present, PET is the only technique that provides accurate, quantitative in vivo regional measurements of both cerebral circulation and cellular metabolism in human subjects. This article reviews normal human cerebral blood flow and metabolism, and human PET studies of ischemic stroke, carotid artery disease, vascular dementia, intracerebral hemorrhage, and aneurysmal subarachnoid hemorrhage, and discusses how these studies have added to the understanding of the pathophysiology of human cerebrovascular disease.

KW - Cerebral blood flow

KW - Cerebral hemodynamics

KW - Cerebral metabolism

KW - Cerebrovascular disease

KW - Positron emission tomography

KW - Vascular dementia

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JO - PET Clinics

JF - PET Clinics

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PET in cerebrovascular disease

Abstract

Keywords

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