The metabolism of exogenous and endogenous substrates, under baseline conditions and in response to metabolic and physiological stimuli, is necessary to maintain cardiac myocyte health. This chapter describes several key advances in positron emission tomography (PET) metabolic imaging. It highlights their contribution to cardiovascular research. The chapter reviews the potential new clinical applications. It discusses how current and newly developed PET metabolic imaging techniques can help characterize these chronic adaptations in various disease processes. The chapter also discusses some of the major advances that have recently occurred in the application of these techniques in small animal imaging and in the development of novel PET radiotracers to measure fatty acid (FA) metabolism and the downstream effects of altered metabolism. Sex has a major impact on myocardial metabolism. The metabolic phenotype in type 2 diabetes mellitus is typified by an overdependence on FA metabolism and a decrease in glucose use.

Original languageEnglish
Title of host publicationCardiac CT, PET and MR
Number of pages28
ISBN (Electronic)9781118754467
ISBN (Print)9781118754504
StatePublished - Jan 1 2019


  • Cardiac myocyte health
  • Diabetes mellitus
  • Fatty acid metabolism
  • Myocardial metabolism
  • Positron emission tomography metabolic imaging


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