TY - JOUR
T1 - Pet and mr studies of experimental focal stroke
AU - Brownell, Anna Liisa
AU - Kano, Michihisa
AU - McKinstry, Robert C.
AU - Moskowitz, Michael A.
AU - Rosen, Bruce R.
AU - Brownell, Gordon L.
PY - 1991/5
Y1 - 1991/5
N2 - Positron emission tomography (PET) and MR have been compared with histochemical pathology to show affected tissue areas in rat brain after right middle cerebral artery (MCA) occlusion combined with temporary bilateral common carotid artery occlusion in Long Evans rats. The glucose metabolic rate was 65 ± 8 μmol/100 ml/min in the right cortical gray matter corresponding to the occluded middle cerebral artery territory and 93 ± 8 μmol/100 ml/min in the corresponding (left) normal side. Infarcted tissue showed decreased PET activity and increased signal in MR T2-weighted scans ipsilateral to the MCA occlusion. These regions correspond to a zone of focal infarction identified in coronal tissue sections stained with 3-4-5 triphenyl tetrazolium chloride. This study demonstrates that PET can be used to study glucose utilization in rat stroke model in vivo and noninvasively.
AB - Positron emission tomography (PET) and MR have been compared with histochemical pathology to show affected tissue areas in rat brain after right middle cerebral artery (MCA) occlusion combined with temporary bilateral common carotid artery occlusion in Long Evans rats. The glucose metabolic rate was 65 ± 8 μmol/100 ml/min in the right cortical gray matter corresponding to the occluded middle cerebral artery territory and 93 ± 8 μmol/100 ml/min in the corresponding (left) normal side. Infarcted tissue showed decreased PET activity and increased signal in MR T2-weighted scans ipsilateral to the MCA occlusion. These regions correspond to a zone of focal infarction identified in coronal tissue sections stained with 3-4-5 triphenyl tetrazolium chloride. This study demonstrates that PET can be used to study glucose utilization in rat stroke model in vivo and noninvasively.
KW - Emission computed tomography-Animal studies-Brain
KW - Glucose
KW - Ischemia-Magnetic resonance imaging-Metabolism
UR - http://www.scopus.com/inward/record.url?scp=0025854669&partnerID=8YFLogxK
U2 - 10.1097/00004728-199105000-00006
DO - 10.1097/00004728-199105000-00006
M3 - Article
C2 - 2026795
AN - SCOPUS:0025854669
SN - 0363-8715
VL - 15
SP - 376
EP - 380
JO - Journal of computer assisted tomography
JF - Journal of computer assisted tomography
IS - 3
ER -