Perspectives of zebrafish models of epilepsy: What, how and where next?

Adam Michael Stewart, Daniel Desmond, Evan Kyzar, Siddharth Gaikwad, Andrew Roth, Russell Riehl, Christopher Collins, Louis Monnig, Jeremy Green, Allan V. Kalueff

Research output: Contribution to journalReview articlepeer-review

85 Scopus citations

Abstract

Epilepsy is a complex brain disorder with multiple underlying causes and poorly understood pathogenetic mechanisms. Animal models have been indispensable tools in experimental epilepsy research. Zebrafish (Danio rerio) are rapidly emerging as a promising model organism to study various brain disorders. Seizure-like behavioral and neurophysiological responses can be evoked in larval and adult zebrafish by various pharmacological and genetic manipulations, collectively emphasizing the growing utility of this model for studying epilepsy. Here, we discuss recent developments in using zebrafish models to study the seizure-like behavior involved in epilepsy, outlining current challenges and strategies for further translational research in this field.

Original languageEnglish
Pages (from-to)135-143
Number of pages9
JournalBrain Research Bulletin
Volume87
Issue number2-3
DOIs
StatePublished - Feb 10 2012

Keywords

  • Antiepileptic drugs
  • Biomarkers
  • Disease model
  • Epilepsy
  • Epileptogenesis
  • Seizure
  • Zebrafish

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