Personalized cancer vaccines: Targeting the cancer mutanome

Xiuli Zhang, Piyush K. Sharma, S. Peter Goedegebuure, William E. Gillanders

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

The development of next generation sequencing technologies has revolutionized our understanding of how specific genetic events contribute to cancer initiation and progression. Dramatic improvements in instrument design and efficiency, combined with significant cost reductions has permitted a systematic analysis of the mutational landscape in a variety of cancer types. At the same time, a detailed map of the cancer mutanome in individual cancers offers a unique opportunity to develop personalized cancer vaccine strategies targeting neoantigens. Recent studies in both preclinical models and human cancer patients demonstrate that neoantigens (1) are important targets following checkpoint inhibition therapy, (2) have been identified as the target of adoptive T cell therapies, and (3) can be successfully targeted with personalized vaccines. Taken together, these observations provide strong rationale for the clinical translation of personalized cancer vaccines.

Original languageEnglish
Pages (from-to)1094-1100
Number of pages7
JournalVaccine
Volume35
Issue number7
DOIs
StatePublished - Feb 15 2017

Keywords

  • Cancer vaccine
  • Genome sequencing
  • Neoantigen
  • Personalized

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