Personality disorder scores improve with effective pharmacotherapy of depression

Kevin John Black, Yvette I. Sheline

Research output: Contribution to journalArticlepeer-review

79 Scopus citations


Introduction: We hypothesized that the probability of personality disorder ('PROB') predicted by the Temperament and Character Inventory ('TCI') would decline after successful pharmacotherapy of depression. Methods: We administered a computerized version of the TCI to 15 patients with DSM-III-R major depression, before and after treatment with serotonergic antidepressants. Results: PROB declined from 58.9% ± 18.0% to 42.4% ± 22.8% (P < 0.003), due to a significant increase in the Self-Directedness scale. This change in PROB correlated with improvement in self-rated severity of depression (P < 0.02). Conclusion: TCI prediction of personality disorder is susceptible to state effects of depression.

Original languageEnglish
Pages (from-to)11-18
Number of pages8
JournalJournal of affective disorders
Issue number1
StatePublished - Mar 1 1997


  • Character
  • Depressive disorder
  • Personality disorders
  • Personality inventory
  • Psychometrics
  • Reproducibility of results


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