TY - JOUR
T1 - Personality and the genetic risk for alcohol dependence
AU - Slutske, Wendy S.
AU - Heath, Andrew C.
AU - Madden, Pamela A.F.
AU - Bucholz, Kathleen K.
AU - Statham, Dixie J.
AU - Martin, Nicholas G.
PY - 2002
Y1 - 2002
N2 - The extent to which the genetic risk for alcohol dependence (AD) and conduct disorder (CD) and their common genetic risk overlap with genetic factors contributing to variation in dimensions of personality was examined in a study of 6,453 individuals from 3,383 adult male and female same-sex and unlike-sex twin pairs from the Australian Twin Registry. The associations between the personality dimensions of positive emotionality, negative emotionality, and AD and CD risk were modest, whereas the associations between behavioral undercontrol and AD and CD risk were substantially higher. Genetic influences contributing to variation in behavioral undercontrol accounted for about 40% of the genetic variation in AD and CD risk and about 90% of the common genetic risk for AD and CD. These results suggest that genetic factors contributing to variation in dimensions of personality, particularly behavioral undercontrol, account for a substantial proportion of the genetic diathesis for AD and most of the common genetic diathesis for AD and CD among both men and women.
AB - The extent to which the genetic risk for alcohol dependence (AD) and conduct disorder (CD) and their common genetic risk overlap with genetic factors contributing to variation in dimensions of personality was examined in a study of 6,453 individuals from 3,383 adult male and female same-sex and unlike-sex twin pairs from the Australian Twin Registry. The associations between the personality dimensions of positive emotionality, negative emotionality, and AD and CD risk were modest, whereas the associations between behavioral undercontrol and AD and CD risk were substantially higher. Genetic influences contributing to variation in behavioral undercontrol accounted for about 40% of the genetic variation in AD and CD risk and about 90% of the common genetic risk for AD and CD. These results suggest that genetic factors contributing to variation in dimensions of personality, particularly behavioral undercontrol, account for a substantial proportion of the genetic diathesis for AD and most of the common genetic diathesis for AD and CD among both men and women.
UR - http://www.scopus.com/inward/record.url?scp=0036168949&partnerID=8YFLogxK
U2 - 10.1037/0021-843X.111.1.124
DO - 10.1037/0021-843X.111.1.124
M3 - Article
C2 - 11871377
AN - SCOPUS:0036168949
SN - 0021-843X
VL - 111
SP - 124
EP - 133
JO - Journal of Abnormal Psychology
JF - Journal of Abnormal Psychology
IS - 1
ER -