Persistent inflammation with pedal osteolysis 1 year after Charcot neuropathic osteoarthropathy

David R. Sinacore, Kathryn L. Bohnert, Kirk E. Smith, Mary K. Hastings, Paul K. Commean, David J. Gutekunst, Jeffrey E. Johnson, Fred W. Prior

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Aims To determine local and systemic markers of inflammation and bone mineral density (BMD) in the foot and central sites in participants with diabetes mellitus and peripheral neuropathy (DMPN) with and without acute Charcot neuropathic osteoarthropathy (CN). Methods Eighteen participants with DMPN and CN and 19 participants without CN had foot temperature assessments, serum markers of inflammation [C-reactive protein, (CRP) and erythrocyte sedimentation rate, (ESR)] and BMD of the foot, hip and lumbar spine at baseline and 1 year follow-up. Results CN foot temperature difference was higher compared to DMPN controls at baseline (4.2 ± 1.9 °F vs. 1.2 ± 0.9 °F, P < 0.01) and after 1 year (2.9 ± 3.2 °F vs. 0.9 ± 1.1 °F, P < 0.01). Serum inflammatory markers in the CN group were greater at baseline and remained elevated 1 year later compared to DMPN controls (CRP, P = 0.02, ESR, P = 0.03). All pedal bones' BMD decreased an average of 3% in the CN foot with no changes in hip or lumbar spine. DMPN controls' foot, hip and lumbar spine BMD remained unchanged. Conclusions Local and systemic inflammation persists 1 year after CN with an accompanying pedal osteolysis that may contribute to mid foot deformity which is the hallmark of the chronic Charcot foot.

Original languageEnglish
Pages (from-to)1014-1020
Number of pages7
JournalJournal of Diabetes and Its Complications
Issue number6
StatePublished - Jun 2017


  • Bone mineral density
  • Charcot foot
  • Foot deformity
  • Inflammatory osteolysis
  • Skin temperature


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