Persistence of TCDD in monkey adipose tissue

W. P. McNulty; K. A. nielsen-smith; J. O. lay; D. L. lippstreu; N. L. kangas; P. A. lyon; M. L. gross

doi:10.1016/s0015-6264(82)80272-1

Persistence of TCDD in monkey adipose tissue

W. P. McNulty, K. A. nielsen-smith, J. O. lay, D. L. lippstreu, N. L. kangas, P. A. lyon, M. L. gross

Research output: Contribution to journal › Letter › peer-review

Original language	English
Pages (from-to)	985-986
Number of pages	2
Journal	Food and Cosmetics Toxicology
Volume	20
Issue number	6
DOIs	https://doi.org/10.1016/s0015-6264(82)80272-1
State	Published - 1982

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10.1016/s0015-6264(82)80272-1

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@article{75859e374da84160acb120768d65d8ad,

title = "Persistence of TCDD in monkey adipose tissue",

author = "McNulty, {W. P.} and nielsen-smith, {K. A.} and lay, {J. O.} and lippstreu, {D. L.} and kangas, {N. L.} and lyon, {P. A.} and gross, {M. L.}",

note = "Funding Information: primarily in adipose tissue. total body fat was reduced roughly five-fold, and this factor corresponds to the increase in the concentration of TCDD in fat between days 4 and 64. After 2 yr. the body weight of the monkey was about the same as it was 4 days after the dose. and the concentration of TCDD in fat was roughly 257” of the day-4 level. Thus, the apparent half-life of TCDD in fat in this animal was about I yr. Too little liver tissue was available from the needle biopsies for measurement of TCDD; only the larger sample taken at 2yr was analysed. However, if the level of hepatic AHH activity is an indication of the amount of TCDD in the liver, much of the compound stored in that organ early on must have been soon excreted or translocated. This inference is in agreement with the finding of Van Miller et nl. (/or. cit.) that 7 days after a dose of tritiated TCDD to rhesus macaques, most of the radioactive label was in fat-containing tissues (adipose tissue, skin and muscle). and not in the liver. Furthermore, we speculate that the toxicity of TCDD for rhesus macaques does not correlate well with the amount sequestered in body fat, because the monkey began to gain weight 3 months after the dose and has been healthy since. The potential late adverse effects for rhesus macaques of long-term TCDD persistence in adipose tissue remain to be investigated. This work was supported by Grants ES-01522 and RR-05694 of the National Institutes of Health, by the Midwest Center for Mass Spectrometry, a National Science Foundation regional instrumentation facility (Grant CHE-78-18572) and by the US Environmental Protection Agency (Cooperative Agreement CR-806847-01).",

year = "1982",

doi = "10.1016/s0015-6264(82)80272-1",

language = "English",

volume = "20",

pages = "985--986",

journal = "Food and Cosmetics Toxicology",

issn = "0015-6264",

number = "6",

}

TY - JOUR

T1 - Persistence of TCDD in monkey adipose tissue

AU - McNulty, W. P.

AU - nielsen-smith, K. A.

AU - lay, J. O.

AU - lippstreu, D. L.

AU - kangas, N. L.

AU - lyon, P. A.

AU - gross, M. L.

N1 - Funding Information: primarily in adipose tissue. total body fat was reduced roughly five-fold, and this factor corresponds to the increase in the concentration of TCDD in fat between days 4 and 64. After 2 yr. the body weight of the monkey was about the same as it was 4 days after the dose. and the concentration of TCDD in fat was roughly 257” of the day-4 level. Thus, the apparent half-life of TCDD in fat in this animal was about I yr. Too little liver tissue was available from the needle biopsies for measurement of TCDD; only the larger sample taken at 2yr was analysed. However, if the level of hepatic AHH activity is an indication of the amount of TCDD in the liver, much of the compound stored in that organ early on must have been soon excreted or translocated. This inference is in agreement with the finding of Van Miller et nl. (/or. cit.) that 7 days after a dose of tritiated TCDD to rhesus macaques, most of the radioactive label was in fat-containing tissues (adipose tissue, skin and muscle). and not in the liver. Furthermore, we speculate that the toxicity of TCDD for rhesus macaques does not correlate well with the amount sequestered in body fat, because the monkey began to gain weight 3 months after the dose and has been healthy since. The potential late adverse effects for rhesus macaques of long-term TCDD persistence in adipose tissue remain to be investigated. This work was supported by Grants ES-01522 and RR-05694 of the National Institutes of Health, by the Midwest Center for Mass Spectrometry, a National Science Foundation regional instrumentation facility (Grant CHE-78-18572) and by the US Environmental Protection Agency (Cooperative Agreement CR-806847-01).

PY - 1982

Y1 - 1982

UR - http://www.scopus.com/inward/record.url?scp=0020441867&partnerID=8YFLogxK

U2 - 10.1016/s0015-6264(82)80272-1

DO - 10.1016/s0015-6264(82)80272-1

M3 - Letter

AN - SCOPUS:0020441867

SN - 0015-6264

VL - 20

SP - 985

EP - 986

JO - Food and Cosmetics Toxicology

JF - Food and Cosmetics Toxicology

IS - 6

ER -

Persistence of TCDD in monkey adipose tissue

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