@article{82cd6cd4843d491098695465df5168a5,
title = "Persephin, a novel neurotrophic factor related to GDNF and neurturin",
abstract = "A novel nuerotrophic factor named ~40% Persephin that is to glial cell lied neurotrophic factor (GDNF) and neurturin (NTN) has been identified using degenerate PCR. Persephin, like GDNF and NTN, promotes the survival of ventral midbrain dopaminergic neurons in culture and prevents their degeneration after 6-hydroxydopamine treatment in vivo. Persephin also supports the survival of motor neurons in culture end in vivo after sciatic nerve axotomy and, like GDNF, promotes ureteric bud branching. However, in contrast to GDNF and NTN, persephin does not support any of the peripheral neurons that were examined. Fibroblasts transfected with Rat and one of the coreceptors GFRα-1 or GFRα-2 do not respond to persephin, suggesting that persephin utilizes additional, or different, receptor components than GDNF and NTN.",
author = "Jeffrey Milbrandt and {De Sauvage}, {Frederic J.} and Fahrner, {Timothy J.} and Baloh, {Robert H.} and Leitner, {Melanie L.} and Tansey, {Mal{\'u} G.} and Lampe, {Patricia A.} and Heuckeroth, {Robert O.} and Kotzbauer, {Paul T.} and Simburger, {Kelli S.} and Golden, {Judith P.} and Davies, {Jamie A.} and Richard Vejsada and Kato, {Ann C.} and Mary Hynes and Daniel Sherman and Merry Nishimura and Wang, {Li Chong} and Richard Vandlen and Barbara Moffat and Klein, {Robert D.} and Kris Poulsen and Christa Gray and Alain Garces and Henderson, {Christopher E.} and Phillips, {Heidi S.} and Johnson, {Eugene M.}",
note = "Funding Information: We thank P. Osborne, S. Audrain, B. King, and L. Simmons for their outstanding technical support and B. Devaux for helpful suggestions. This work was supported by National Institutes of Health grants R01 AG13729 (E. M. J.) and R01 AG13730 (J. M.), Royal Society grant #16275 (J. A. D.), Swiss National Science Foundation and Association Francaise contre les Myopathies (A. C. K.), AFM and IRME (C. E. H.), and Genentech. Washington University, E. M. J., and J. M. may receive income based on a license to Genentech. ",
year = "1998",
month = feb,
doi = "10.1016/S0896-6273(00)80453-5",
language = "English",
volume = "20",
pages = "245--253",
journal = "Neuron",
issn = "0896-6273",
number = "2",
}