TY - JOUR
T1 - Peroxisomes
T2 - A nexus for lipid metabolism and cellular signaling
AU - Lodhi, Irfan J.
AU - Semenkovich, Clay F.
N1 - Funding Information:
This work was supported by NIH grants DK076729, DK088083, T32 DK007120, DK20579, DK56341, and K99 DK094874.
PY - 2014/3/4
Y1 - 2014/3/4
N2 - Peroxisomes are often dismissed as the cellular hoi polloi, relegated to cleaning up reactive oxygen chemical debris discarded by other organelles. However, their functions extend far beyond hydrogen peroxide metabolism. Peroxisomes are intimately associated with lipid droplets and mitochondria, and their ability to carry out fatty acid oxidation and lipid synthesis, especially the production of ether lipids, may be critical for generating cellular signals required for normal physiology. Here, we review the biology of peroxisomes and their potential relevance to human disorders including cancer, obesity-related diabetes, and degenerative neurologic disease.
AB - Peroxisomes are often dismissed as the cellular hoi polloi, relegated to cleaning up reactive oxygen chemical debris discarded by other organelles. However, their functions extend far beyond hydrogen peroxide metabolism. Peroxisomes are intimately associated with lipid droplets and mitochondria, and their ability to carry out fatty acid oxidation and lipid synthesis, especially the production of ether lipids, may be critical for generating cellular signals required for normal physiology. Here, we review the biology of peroxisomes and their potential relevance to human disorders including cancer, obesity-related diabetes, and degenerative neurologic disease.
UR - http://www.scopus.com/inward/record.url?scp=84896731135&partnerID=8YFLogxK
U2 - 10.1016/j.cmet.2014.01.002
DO - 10.1016/j.cmet.2014.01.002
M3 - Review article
C2 - 24508507
AN - SCOPUS:84896731135
SN - 1550-4131
VL - 19
SP - 380
EP - 392
JO - Cell metabolism
JF - Cell metabolism
IS - 3
ER -