Peroxisomes: A nexus for lipid metabolism and cellular signaling

Research output: Contribution to journalReview article

168 Scopus citations

Abstract

Peroxisomes are often dismissed as the cellular hoi polloi, relegated to cleaning up reactive oxygen chemical debris discarded by other organelles. However, their functions extend far beyond hydrogen peroxide metabolism. Peroxisomes are intimately associated with lipid droplets and mitochondria, and their ability to carry out fatty acid oxidation and lipid synthesis, especially the production of ether lipids, may be critical for generating cellular signals required for normal physiology. Here, we review the biology of peroxisomes and their potential relevance to human disorders including cancer, obesity-related diabetes, and degenerative neurologic disease.

Original languageEnglish
Pages (from-to)380-392
Number of pages13
JournalCell metabolism
Volume19
Issue number3
DOIs
StatePublished - Mar 4 2014

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