TY - JOUR
T1 - Peroxisome Proliferator Activated Receptor-Alpha (PPARα) and PPAR gamma coactivator-1alpha (PGC-1α) regulation of cardiac metabolism in diabetes
AU - Duncan, Jennifer G.
N1 - Funding Information:
Jennifer G. Duncan, a Faculty Scholar of the Children’s Discovery Institute at Washington University School of Medicine, is supported by an NHLBI K08 award (HL084093).
PY - 2011/3
Y1 - 2011/3
N2 - Cardiovascular disease is a leading cause of mortality among patients with diabetes, and heart failure exists even in the absence of coronary disease. Myocardial metabolism is altered in the diabetic heart as a result of changes in substrate availability secondary to insulin resistance. The nuclear receptor peroxisome proliferator activated receptor-alpha (PPARα) and PPAR-gamma coactivator-1alpha (PGC-1α) play important roles in transcriptional regulation of myocardial metabolism and contribute significantly to the changes that occur in the diabetic heart. This review summarizes the role of PPARα and PGC-1α in myocardial metabolism in the normal heart and in the diabetic heart.
AB - Cardiovascular disease is a leading cause of mortality among patients with diabetes, and heart failure exists even in the absence of coronary disease. Myocardial metabolism is altered in the diabetic heart as a result of changes in substrate availability secondary to insulin resistance. The nuclear receptor peroxisome proliferator activated receptor-alpha (PPARα) and PPAR-gamma coactivator-1alpha (PGC-1α) play important roles in transcriptional regulation of myocardial metabolism and contribute significantly to the changes that occur in the diabetic heart. This review summarizes the role of PPARα and PGC-1α in myocardial metabolism in the normal heart and in the diabetic heart.
KW - Cardiovascular disease
KW - Diabetes
KW - Myocardial metabolism
KW - PPAR-gamma coactivator-1alpha
KW - Proliferator activated receptor-alpha
UR - http://www.scopus.com/inward/record.url?scp=79953765816&partnerID=8YFLogxK
U2 - 10.1007/s00246-011-9889-8
DO - 10.1007/s00246-011-9889-8
M3 - Article
C2 - 21286700
AN - SCOPUS:79953765816
SN - 0172-0643
VL - 32
SP - 323
EP - 328
JO - Pediatric Cardiology
JF - Pediatric Cardiology
IS - 3
ER -