Peroxisome Proliferator Activated Receptor-Alpha (PPARα) and PPAR gamma coactivator-1alpha (PGC-1α) regulation of cardiac metabolism in diabetes

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Abstract

Cardiovascular disease is a leading cause of mortality among patients with diabetes, and heart failure exists even in the absence of coronary disease. Myocardial metabolism is altered in the diabetic heart as a result of changes in substrate availability secondary to insulin resistance. The nuclear receptor peroxisome proliferator activated receptor-alpha (PPARα) and PPAR-gamma coactivator-1alpha (PGC-1α) play important roles in transcriptional regulation of myocardial metabolism and contribute significantly to the changes that occur in the diabetic heart. This review summarizes the role of PPARα and PGC-1α in myocardial metabolism in the normal heart and in the diabetic heart.

Original languageEnglish
Pages (from-to)323-328
Number of pages6
JournalPediatric Cardiology
Volume32
Issue number3
DOIs
StatePublished - Mar 2011

Keywords

  • Cardiovascular disease
  • Diabetes
  • Myocardial metabolism
  • PPAR-gamma coactivator-1alpha
  • Proliferator activated receptor-alpha

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