Peroxisomal Dysfunction in Age-Related Diseases

Cynthia M. Cipolla, Irfan J. Lodhi

Research output: Contribution to journalReview article

38 Scopus citations

Abstract

Peroxisomes carry out many key functions related to lipid and reactive oxygen species (ROS) metabolism. The fundamental importance of peroxisomes for health in humans is underscored by the existence of devastating genetic disorders caused by impaired peroxisomal function or lack of peroxisomes. Emerging studies suggest that peroxisomal function may also be altered with aging and contribute to the pathogenesis of a variety of diseases, including diabetes and its related complications, neurodegenerative disorders, and cancer. With increasing evidence connecting peroxisomal dysfunction to the pathogenesis of these acquired diseases, the possibility of targeting peroxisomal function in disease prevention or treatment becomes intriguing. Here, we review recent developments in understanding the pathophysiological implications of peroxisomal dysfunctions outside the context of inherited peroxisomal disorders.

Original languageEnglish
Pages (from-to)297-308
Number of pages12
JournalTrends in Endocrinology and Metabolism
Volume28
Issue number4
DOIs
StatePublished - Apr 1 2017

Keywords

  • aging
  • neurodegeneration
  • peroxisome
  • pexophagy
  • reactive oxygen species

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