Permeability to potassium of the endolymph-perilymph barrier and its possible relation to hair cell function

T. Konishi, A. N. Salt

Research output: Contribution to journalArticlepeer-review

55 Scopus citations

Abstract

The endocochlear potential and potassium concentrations in endolymph and perilymph were simultaneously measured in the basal turn of the guinea pig cochlea with double-barreled K+ selective electrodes. The K+ conductance and K+ permeability coefficient of the endolymph-perilymph barrier were calculated from the rate of change of endolymph K+ concentration relative to the K+ electrochemical potential difference recorded during permanent anoxia. When anoxia was induced in guinea pigs treated with kanamycin, the rate of decline of the electrochemical potential difference for K+ between the endolymph and perilymph was reduced when compared to normal guinea pigs. In guinea pigs exposed to broad band noise at 115 dBA for periods from 11-15 days, the rate of decline of the electrochemical potential difference for K+ across the endolymph-perilymph barrier was reduced but not to the extent found in guinea pigs treated with kanamycin. The K+ conductance and K+ permeability coefficient of the endolymph-perilymph barrier showed substantial decreases in noise exposed and kanamycin treated guinea pigs, as compared to normal guinea pigs. The magnitude of decrease of K+ permeability of the endolymph-perilymph barrier by noise or kanamycin was correlated with suppression of the maximum output of the cochlear microphonic.

Original languageEnglish
Pages (from-to)457-463
Number of pages7
JournalExperimental Brain Research
Volume40
Issue number4
DOIs
StatePublished - Nov 1 1980

Keywords

  • Anoxia
  • Electrochemical potential
  • Endolymph-perilymph barrier
  • K permeability

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